{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:10:17Z","timestamp":1758633017159},"reference-count":21,"publisher":"Microbiology Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,12,1]]},"abstract":"Rinderpest, or cattle plague, is caused by Rinderpest virus<\/jats:italic> (RPV), which is related most closely to human Measles virus<\/jats:italic> (MV), both being members of the genus Morbillivirus<\/jats:italic>, a group of viruses known to have strong immunosuppressive effects in vitro<\/jats:italic> and in vivo<\/jats:italic>. Here, it was shown that peripheral blood mononuclear cells (PBMCs) isolated from cattle experimentally infected with either wild-type or vaccine strains of RPV impaired the proliferation of PBMCs derived from uninfected animals; however, in contrast to either mild or virulent strains of wild-type virus, the inhibition induced by the vaccine was both weak and transient. Flow-cytometric analysis of PBMCs obtained from cattle infected with different strains of RPV showed that the proportion of infected cells was virus dose-dependent and correlated with lymphoproliferative suppression.<\/jats:p>","DOI":"10.1099\/vir.0.81370-0","type":"journal-article","created":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T02:23:23Z","timestamp":1132280603000},"page":"3349-3355","source":"Crossref","is-referenced-by-count":16,"title":["Inhibition of host peripheral blood mononuclear cell proliferation ex vivo by Rinderpest virus"],"prefix":"10.1099","volume":"86","author":[{"given":"J.","family":"Heaney","sequence":"first","affiliation":[{"name":"Institute for Animal Health, Ash Road, Pirbright, Surrey GU24 0NF, UK"},{"name":"The Queens University of Belfast, Microbiology, Royal Victoria Hospital, Belfast BT12 6BN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. L.","family":"Cosby","sequence":"additional","affiliation":[{"name":"The Queens University of Belfast, Microbiology, Royal Victoria Hospital, Belfast BT12 6BN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Barrett","sequence":"additional","affiliation":[{"name":"Institute for Animal Health, Ash Road, Pirbright, Surrey GU24 0NF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1136\/vr.142.24.669","article-title":"Rediscovery of the second African lineage of rinderpest virus: its epidemiological significance","volume":"142","author":"Barrett","year":"1998","journal-title":"Vet Rec"},{"key":"R2","first-page":"89","article-title":"Development of new generation rinderpest vaccines","volume":"114","author":"Barrett","year":"2003","journal-title":"Dev Biol (Basel"},{"key":"R3","first-page":"1267","article-title":"Measles virus. 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