{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T14:10:16Z","timestamp":1674915016300},"reference-count":21,"publisher":"Microbiology Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,2,1]]},"abstract":"<jats:p>Chronic carriers of hepatitis B infection often harbour virus strains with mutations in the precore region. These mutations are temporally associated with the development of HBeAg loss and seroconversion to anti-HBe. The most common precore mutation is a stop codon at position 1896, but other mutations leading to abolished HBeAg secretion have been described. Here, a novel precore mutation introducing a lysine in the precore position 28, a sequence shared by non-human primates but not by other human isolates, is described. However, the insertion causes a frame-shift preventing the expression of HBeAg by introducing a stop codon 5\u2005aa downstream of the mutation. Analysis of the predicted RNA secondary structure indicates that the insertion could occur without fatally affecting the stability of the stem\u2013loop encapsidation signal.<\/jats:p>","DOI":"10.1099\/vir.0.81562-0","type":"journal-article","created":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T21:02:31Z","timestamp":1138050151000},"page":"307-310","source":"Crossref","is-referenced-by-count":4,"title":["Novel mutation in Hepatitis B virus preventing HBeAg production and resembling primate strains"],"prefix":"10.1099","volume":"87","author":[{"given":"M.","family":"Ingman","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Lund University, 22185 Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Lindqvist","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Lund University, 22185 Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kidd-Ljunggren","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Lund University, 22185 Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/(SICI)1096-9071(200002)60:2<107::AID-JMV1>3.0.CO;2-T","article-title":"Genotypic differences in the hepatitis B virus core promoter and precore sequences during seroconversion from HBeAg to anti-HBe","volume":"60","author":"Bl\u00e4ckberg","year":"2000","journal-title":"J Med Virol"},{"key":"R2","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/S0140-6736(89)90713-7","article-title":"Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B 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