{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:51:48Z","timestamp":1790898708026,"version":"4.1.0"},"reference-count":36,"publisher":"Microbiology Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,9,1]]},"abstract":"<jats:p>Previously, it was shown that the 3\u2032 untranslated region (3\u2032UTR) of Kamiti River virus (KRV) is nearly twice as long as the 3\u2032UTR of other flaviviruses (1208\u2005nucleotides compared with 730\u2005nucleotides for the longest 3\u2032UTR of any virus in the <jats:italic>Tick-borne encephalitis virus<\/jats:italic> species). Additionally, KRV and the closely related Cell fusing agent virus (CFAV) were shown to contain two short, almost perfect repeat sequences of 67\u2005nucleotides. However, the construction of a robust comparative nucleotide alignment has now revealed that the double-length 3\u2032UTR and the direct repeats resulted from the virtually complete duplication of a primordial KRV 3\u2032UTR. We also propose that the CFAV 3\u2032UTR was derived from a KRV-like precursor sequence with a large deletion that nevertheless preserved the two direct repeat sequences. These data provide new insights into the evolution of the flavivirus 3\u2032UTR.<\/jats:p>","DOI":"10.1099\/vir.0.81950-0","type":"journal-article","created":{"date-parts":[[2006,8,7]],"date-time":"2006-08-07T21:02:46Z","timestamp":1154984566000},"page":"2615-2619","source":"Crossref","is-referenced-by-count":31,"title":["The 3\u2032 untranslated regions of Kamiti River virus and Cell fusing agent virus originated by self-duplication"],"prefix":"10.1099","volume":"87","author":[{"given":"T. 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