{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:26:04Z","timestamp":1791278764641,"version":"4.1.0"},"reference-count":39,"publisher":"Microbiology Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,1,1]]},"abstract":"<jats:p>The yellow fever virus attenuated 17D vaccine strain is a safe and effective vaccine and a valuable model system for evaluating immune responses against attenuated viral variants. This study compared the<jats:italic>in vitro<\/jats:italic>interactions of the commercially available yellow fever vaccine (YF-VAX),<jats:italic>Dengue virus<\/jats:italic>and the live-attenuated dengue vaccine PDK50 with dendritic cells (DCs), the main antigen-presenting cells at the initiation of immune responses. Similar to PDK50, infection with YF-VAX generated activated DCs; however, for YF-VAX, activation occurred with limited intracellular virus replication. The majority of internalized virus co-localized with endolysosomal markers within 90\u2005min, suggesting that YF-VAX is processed rapidly in DCs. These results indicate that restricted virus replication and lysosomal compartmentalization may be important contributing factors to the success of the YF-VAX vaccine.<\/jats:p>","DOI":"10.1099\/vir.0.82272-0","type":"journal-article","created":{"date-parts":[[2006,12,15]],"date-time":"2006-12-15T01:42:25Z","timestamp":1166146945000},"page":"148-156","source":"Crossref","is-referenced-by-count":31,"title":["Restricted replication and lysosomal trafficking of yellow fever 17D vaccine virus in human dendritic cells"],"prefix":"10.1099","volume":"88","author":[{"given":"Dupeh R.","family":"Palmer","sequence":"first","affiliation":[{"name":"Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, MD, 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