{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:43:51Z","timestamp":1783111431173,"version":"3.54.6"},"reference-count":19,"publisher":"Microbiology Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,7,1]]},"abstract":"<jats:p>The utility of rectal lymphoid tissue sampling for the diagnosis of chronic wasting disease (CWD) infections in mule deer (<jats:italic>Odocoileus hemionus<\/jats:italic>) and white-tailed deer (<jats:italic>Odocoileus virginianus<\/jats:italic>) was evaluated. CWD-associated prion protein (PrP<jats:sup>CWD<\/jats:sup>) deposits were observed in the rectal mucosa from 19 orally inoculated mule deer by 381 days post-inoculation (p.i.); similarly, 45 out of 50 naturally infected mule deer had PrP<jats:sup>CWD<\/jats:sup> in their rectal mucosa. In orally inoculated white-tailed deer, the presence of glycine (G) or serine (S) at codon 96 of the native PrP (denoted 96GG, 96GS or 96SS) appeared to influence the temporal patterns of PrP<jats:sup>CWD<\/jats:sup> deposition: nine out of 11 infected 96GG individuals had PrP<jats:sup>CWD<\/jats:sup> in their rectal mucosa by 342\u2005days\u2005p.i., whereas only three out of seven infected 96GS individuals had PrP<jats:sup>CWD<\/jats:sup> in their rectal mucosa by 381\u2005days\u2005p.i. and none of three 96SS individuals had PrP<jats:sup>CWD<\/jats:sup> in their rectal mucosa by 751\u2005days\u2005p.i. These findings support further evaluation of rectal mucosa sampling in CWD surveillance.<\/jats:p>","DOI":"10.1099\/vir.0.82342-0","type":"journal-article","created":{"date-parts":[[2007,6,6]],"date-time":"2007-06-06T17:03:19Z","timestamp":1181149399000},"page":"2078-2082","source":"Crossref","is-referenced-by-count":57,"title":["PrPCWD in rectal lymphoid tissue of deer (Odocoileus spp.)"],"prefix":"10.1099","volume":"88","author":[{"given":"Lisa L.","family":"Wolfe","sequence":"first","affiliation":[{"name":"Colorado Division of Wildlife, Wildlife Research Center, 317 West Prospect Road, Fort Collins, CO 80526-2097, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry R.","family":"Spraker","sequence":"additional","affiliation":[{"name":"Colorado State University Veterinary Diagnostic Laboratory, Colorado State University, Fort Collins, CO 80523, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Veterinary Laboratories Agency \u2212 Lasswade, Pentlands Science Park, Penicuik EH26 0PZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P.","family":"Dagleish","sequence":"additional","affiliation":[{"name":"Moredun Research Institute, Pentlands Science Park, Penicuik EH26 0PZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey M.","family":"Sirochman","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University of Wyoming, 1000 E. 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