{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T16:19:49Z","timestamp":1743265189898},"reference-count":17,"publisher":"Microbiology Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,5,1]]},"abstract":"<jats:p>Following acute infection, murine cytomegalovirus (MCMV) replicates persistently in the salivary glands, despite the vigorous response of activated CD8 T cells that infiltrate this gland. Virus-specific CD8 T lymphocytes isolated from this organ were found to express the inhibitory CD94\/NKG2A receptor that, in some virus models, confers an inhibitory response to cytotoxic T lymphocytes (CTLs). In response to MCMV infection, expression of the CD94\/NKG2A ligand, Qa-1<jats:sup>b<\/jats:sup>, increased dramatically in the submandibular gland (SMG) prior to upregulation of H-2D<jats:sup>d<\/jats:sup>. However, there was no net negative impact on virus-specific T-cell function, as virus titres were similar in CD94<jats:sup>\u2212<\/jats:sup> and CD94<jats:sup>+<\/jats:sup> mice. CD94\/NKG2A expression, also known to inhibit apoptosis, did not influence the numbers of accumulated T, NK and NK T cells. These data indicate that expression of inhibitory CD94\/NKG2A receptors does not account for the failure of MCMV-specific CTLs to clear the SMG of infection.<\/jats:p>","DOI":"10.1099\/vir.0.82444-0","type":"journal-article","created":{"date-parts":[[2007,4,5]],"date-time":"2007-04-05T19:24:40Z","timestamp":1175801080000},"page":"1440-1445","source":"Crossref","is-referenced-by-count":12,"title":["Upregulation of CD94\/NKG2A receptors and Qa-1b ligand during murine cytomegalovirus infection of salivary glands"],"prefix":"10.1099","volume":"88","author":[{"given":"Victoria J.","family":"Cavanaugh","sequence":"first","affiliation":[{"name":"Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23501, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H.","family":"Raulet","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology, and Cancer Research Laboratory, University of California, 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