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Analysis of the sequence alignment of 256\u2005aa (S region) from the eight HBV-infected chimpanzees allowed us to determine the HBV amino acid patterns specific to each chimpanzee subspecies and to their geographical origin. Phylogenetic analysis of both the S region and the complete genome confirmed this distinctive clustering of eight novel ChHBV strains within <jats:italic>Pan troglodytes<\/jats:italic>. The strong phylogenetic associations of ChHBV sequences with both chimpanzee subspecies and their geographical origin were therefore confirmed.<\/jats:p>","DOI":"10.1099\/vir.0.82992-0","type":"journal-article","created":{"date-parts":[[2007,9,13]],"date-time":"2007-09-13T21:48:51Z","timestamp":1189720131000},"page":"2679-2685","source":"Crossref","is-referenced-by-count":12,"title":["Complete-genome analysis of hepatitis B virus from wild-born chimpanzees in central Africa demonstrates a strain-specific geographical cluster"],"prefix":"10.1099","volume":"88","author":[{"given":"Maria","family":"Makuwa","sequence":"first","affiliation":[{"name":"Centre International de Recherches M\u00e9dicales de Franceville, Unit\u00e9 de R\u00e9trovirologie et Centre de Primatologie, Franceville, Gabon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Souqui\u00e8re","sequence":"additional","affiliation":[{"name":"Centre International de Recherches M\u00e9dicales 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