{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T15:01:07Z","timestamp":1782572467547,"version":"3.54.5"},"reference-count":22,"publisher":"Microbiology Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,11,1]]},"abstract":"<jats:p>Hepatitis A virus (HAV) is a hepatotropic member of the family <jats:italic>Picornaviridae.<\/jats:italic> Previous studies suggested that HAV may evolve more slowly than other members of the family. To estimate HAV substitution rates precisely, we used a Bayesian Markov chain Monte Carlo (MCMC) approach on temporally sampled HAV VP1 full-length sequences from strains isolated in France. A mean rate of evolutionary change of 9.76\u00d710<jats:sup>\u22124<\/jats:sup> nucleotide substitution per site per year was found. 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