{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T10:32:42Z","timestamp":1789295562055,"version":"build-2803163510"},"reference-count":31,"publisher":"Microbiology Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,11,1]]},"abstract":"<jats:p>Acute-phase sera from &gt;5\u200a% of cases of haemorrhagic fever with renal syndrome occurring annually in Korea have been found to exhibit a fourfold or higher antibody titre to Puumala virus (PUUV) than to Hantaan virus (HTNV) by double-sandwich IgM ELISA, suggesting the existence of a PUUV-related hantavirus. Based on the phylogenetic relationships among arvicolid rodents, the royal vole (<jats:italic>Myodes regulus<\/jats:italic>) was targeted as a likely reservoir host of hantavirus. Using RT-PCR, a genetically distinct hantavirus, designated Muju virus (MUJV), was detected in lung tissue of royal voles, captured in widely separated geographical regions in Korea during 1996\u20132007. Pairwise analysis of the full-length S (1857 nt) and M (3634 nt) segments of MUJV indicated approximately 77\u200a% sequence similarity with PUUV. At the amino acid level, MUJV differed from PUUV by 5.5\u20136.9\u200a% (nucleocapsid) and 10.0\u201311.6\u200a% (Gn and Gc envelope glycoproteins). Interstrain variation of MUJV sequences from royal voles captured in different regions suggested geographic-specific clustering. Neutralizing antibody titres against PUUV were two- to sixfold higher than to HTNV in sera of MUJV-infected<jats:italic>Myodes regulus<\/jats:italic>. Although virus isolation attempts were unsuccessful, the collective data indicate that MUJV is a distinct hantavirus species.<\/jats:p>","DOI":"10.1099\/vir.0.83139-0","type":"journal-article","created":{"date-parts":[[2007,10,18]],"date-time":"2007-10-18T19:27:59Z","timestamp":1192735679000},"page":"3121-3129","source":"Crossref","is-referenced-by-count":53,"title":["Muju virus, a novel hantavirus harboured by the arvicolid rodent Myodes regulus in Korea"],"prefix":"10.1099","volume":"88","author":[{"given":"Ki-Joon","family":"Song","sequence":"first","affiliation":[{"name":"Bank for Pathogenic Viruses, Korea University, Seoul, Korea"},{"name":"Department of Microbiology, College of Medicine, Korea University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luck Ju","family":"Baek","sequence":"additional","affiliation":[{"name":"Bank for Pathogenic Viruses, Korea University, Seoul, Korea"},{"name":"Department of Microbiology, College of Medicine, Korea University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungsil","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Medicine, Korea University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si Jung","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Medicine, Korea University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Medicine, Korea University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Sook","family":"Park","sequence":"additional","affiliation":[{"name":"Bank for Pathogenic Viruses, Korea University, Seoul, Korea"},{"name":"Department of Microbiology, College of Medicine, Korea University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry A.","family":"Klein","sequence":"additional","affiliation":[{"name":"Force Health Protection, 18th Medical Command, Unit 15281, APO AP 96205, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Sames","sequence":"additional","affiliation":[{"name":"Force Health Protection, 18th Medical Command, Unit 15281, APO AP 96205, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heung-Chul","family":"Kim","sequence":"additional","affiliation":[{"name":"5th Medical Detachment, 168th Medical Battalion (Area Support), 18th Medical Command, Unit 15247, APO AP 96205, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Lee","sequence":"additional","affiliation":[{"name":"Virology Division, US Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Yanagihara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, John A. 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