{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:42:40Z","timestamp":1789879360985,"version":"4.0.1"},"reference-count":18,"publisher":"Microbiology Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,4,1]]},"abstract":"<jats:p>We investigated neutralizing antibodies to human papillomavirus type 16 (HPV-16) in serum and cervical washes from 84 women with normal cytology or cervical disease. Serum neutralizing antibodies were detected in 78\u200a% of women infected at the cervix with HPV-16, compared with 35\u200a% (<jats:italic>P<\/jats:italic>=0.002) of women infected with HPV-16-related types (<jats:italic>\u03b1<\/jats:italic>9 HPV types), 14\u200a% (<jats:italic>P<\/jats:italic>&lt;0.0001) of women infected with HPV-16 non-related types and none of HPV-uninfected women. A significant correlation between HPV-16 infection and serum HPV-16-neutralizing antibodies was observed (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>=0.97;<jats:italic>P<\/jats:italic>=0.032). Cervical neutralizing antibodies were detected in 38\u200a% of women with HPV-16 infection and in 17\u200a% of women infected with the HPV-16-related type HPV-31. Cervical neutralizing antibodies correlated with HPV-16 infection (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>=0.95;<jats:italic>P<\/jats:italic>=0.08), but not with cervical disease. Serum and cervical HPV-16 antibody responses were not affected significantly by human immunodeficiency virus type 1 infection. In conclusion, serum and cervical HPV-16-neutralizing antibodies were found to correlate with HPV-16 infection, but not with cervical disease.<\/jats:p>","DOI":"10.1099\/vir.0.83458-0","type":"journal-article","created":{"date-parts":[[2008,3,14]],"date-time":"2008-03-14T06:38:13Z","timestamp":1205476693000},"page":"910-914","source":"Crossref","is-referenced-by-count":13,"title":["Association of serum and mucosal neutralizing antibodies to human papillomavirus type 16 (HPV-16) with HPV-16 infection and cervical disease"],"prefix":"10.1099","volume":"89","author":[{"given":"Zizipho Z. 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