{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:07:17Z","timestamp":1791407237997,"version":"4.3.3"},"reference-count":53,"publisher":"Microbiology Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,5,1]]},"abstract":"<jats:p>Nipah virus (NiV) is a recently emergent, highly pathogenic, zoonotic paramyxovirus of the genus <jats:italic>Henipavirus<\/jats:italic>. Like the phosphoprotein (P) gene of other paramyxoviruses, the P gene of NiV is predicted to encode three additional proteins, C, V and W. When the C, V and W proteins of NiV were tested for their ability to inhibit expression of the chloramphenicol acetyltransferase (CAT) reporter gene in plasmid-based, minigenome replication assays, each protein inhibited CAT expression in a dose-dependent manner. The C, V and W proteins of NiV also inhibited expression of CAT from a measles virus (MV) minigenome, but not from a human parainfluenzavirus 3 (hPIV3) minigenome. Interestingly, the C and V proteins of MV, which have previously been shown to inhibit MV minigenome replication, also inhibited NiV minigenome replication; however, they were not able to inhibit hPIV3 minigenome replication. In contrast, the C protein of hPIV3 inhibited minigenome replication of hPIV3, NiV and MV. Although there is very limited amino acid sequence similarity between the C, V and W proteins within the paramyxoviruses, the heterotypic inhibition of replication suggests that these proteins may share functional properties.<\/jats:p>","DOI":"10.1099\/vir.0.83582-0","type":"journal-article","created":{"date-parts":[[2008,4,17]],"date-time":"2008-04-17T17:33:51Z","timestamp":1208453631000},"page":"1300-1308","source":"Crossref","is-referenced-by-count":64,"title":["The C, V and W proteins of Nipah virus inhibit minigenome replication"],"prefix":"10.1099","volume":"89","author":[{"given":"Katrina","family":"Sleeman","sequence":"first","affiliation":[{"name":"Measles, Mumps, Rubella, and Herpesvirus Laboratory Branch, Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Bankamp","sequence":"additional","affiliation":[{"name":"Measles, Mumps, Rubella, and Herpesvirus 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