{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T19:16:51Z","timestamp":1771874211294,"version":"3.50.1"},"reference-count":34,"publisher":"Microbiology Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,12,1]]},"abstract":"<jats:p>Phenylpropanoids constitute a large part of our daily diet and there is a possibility that they might interact with synthetic drugs. The present work was aimed at studying the interaction of seven phenylpropanoids (cinnamic, <jats:italic>p<\/jats:italic>-coumaric, caffeic, chlorogenic, ferulic, 3,4-dimethoxycinnamic and 2,4,5-trimethoxycinnamic acid) with five antibiotics (amikacin, ampicillin, ciprofloxacin, erythromycin and vancomycin) against Gram-negative (<jats:italic>Escherichia coli<\/jats:italic>, <jats:italic>Enterobacter aerogenes<\/jats:italic> and <jats:italic>Pseudomonas aeruginosa<\/jats:italic>) and Gram-positive (<jats:italic>Staphylococcus aureus<\/jats:italic>) bacteria. The interaction studies were performed by chequerboard and time\u2013kill curve assays. Both assays revealed that cinnamic, <jats:italic>p<\/jats:italic>-coumaric and ferulic acids were the most active. They combined synergistically with the majority of the antibiotics and exhibited enhanced activity against all the micro-organisms. The time\u2013kill curve parameters were better (<jats:italic>P<\/jats:italic>&lt;0.05) for the combinations of amikacin with ferulic, cinnamic or <jats:italic>p<\/jats:italic>-coumaric acid than for the individual treatments. Amikacin was the most favourable antibiotic and <jats:italic>S. aureus<\/jats:italic> was the most sensitive microbe to most of the combinations. These phenylpropanoids damaged the bacterial membrane as assessed by the LIVE\/DEAD<jats:sup\/> \n                  <jats:italic>Bac<\/jats:italic>Light kit, and structure\u2013activity relationship studies indicated that hydrophilic groups enhanced this activity.<\/jats:p>","DOI":"10.1099\/jmm.0.022426-0","type":"journal-article","created":{"date-parts":[[2010,8,20]],"date-time":"2010-08-20T02:25:20Z","timestamp":1282271120000},"page":"1469-1476","source":"Crossref","is-referenced-by-count":87,"title":["Synergistic interaction of phenylpropanoids with antibiotics against bacteria"],"prefix":"10.1099","volume":"59","author":[{"given":"Shanmugam","family":"Hemaiswarya","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600 036, India"}]},{"given":"Mukesh","family":"Doble","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600 036, 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