{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:16:31Z","timestamp":1759335391498},"reference-count":26,"publisher":"Microbiology Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,4,1]]},"abstract":"<jats:p>Although rarely isolated from cystic fibrosis (CF) patients, <jats:italic>Burkholderia dolosa<\/jats:italic> is associated with accelerated lung function decline. During 18 years of epidemiological surveillance in the major Portuguese CF centre in Lisbon, only one patient was infected with <jats:italic>B. dolosa<\/jats:italic>. Pulmonary deterioration, associated with the evolution of forced expiratory volume in 1 s, occurred during 5.5 years of colonization with this <jats:italic>B. dolosa<\/jats:italic> clone (with the new sequence type ST-668). Transient co-colonization with <jats:italic>Burkholderia cenocepacia<\/jats:italic> and other bacterial and fungal pathogens occurred, but <jats:italic>B. dolosa<\/jats:italic> prevailed until the patient\u2019s death. The systematic assessment of relevant phenotypes for the sequential clonal isolates examined in this retrospective study (14 of <jats:italic>B. dolosa<\/jats:italic> and four of <jats:italic>B. cenocepacia<\/jats:italic>) showed that they were variants, although in general no isolation time-dependent pattern of alteration was identified. However, the first <jats:italic>B. dolosa<\/jats:italic> isolate retrieved was more susceptible to gentamicin, imipenem and tobramycin, and exhibited a higher swarming motility compared with most of the isolates obtained during the later stages of disease progression and antimicrobial therapy.<\/jats:p>","DOI":"10.1099\/jmm.0.069849-0","type":"journal-article","created":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T01:51:30Z","timestamp":1390873890000},"page":"594-601","source":"Crossref","is-referenced-by-count":10,"title":["Burkholderia dolosa phenotypic variation during the decline in lung function of a cystic fibrosis patient during 5.5 years of chronic colonization"],"prefix":"10.1099","volume":"63","author":[{"given":"Ana S\u00edlvia","family":"Moreira","sequence":"first","affiliation":[{"name":"IBB \u2013 Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Department of Bioengineering, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, Portugal"}]},{"given":"Carla P.","family":"Coutinho","sequence":"additional","affiliation":[{"name":"IBB \u2013 Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Department of Bioengineering, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, Portugal"}]},{"given":"Pilar","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Consulta de Fibrose Qu\u00edstica, Unidade de Pneumologia, Hospital de Santa Maria, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal"}]},{"given":"Lu\u00eds","family":"Lito","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Patologia Cl\u00ednica, Hospital de Santa Maria, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal"}]},{"given":"Jos\u00e9","family":"Melo-Cristino","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Patologia Cl\u00ednica, Hospital de Santa Maria, Av. 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