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In addition, the genus includes flaviviruses without a known vertebrate reservoir, which have been detected only in insects, particularly in mosquitoes, such as cell fusing agent virus, Kamiti River virus,<jats:italic>Culex<\/jats:italic>flavivirus,<jats:italic>Aedes<\/jats:italic>flavivirus, Quang Binh virus, Nakiwogo virus and Calbertado virus. Reports of the detection of these viruses with no recognized pathogenic role in humans are increasing in mosquitoes collected around the world, particularly in those sampled in entomological surveys targeting pathogenic flaviviruses. The presence of six potential flaviviruses, detected from independent European arbovirus surveys undertaken in the Czech Republic, Italy,Portugal, Spain and the UK between 2007 and 2010, is reported in this work. Whilst the<jats:italic>Aedes<\/jats:italic>flaviviruses, detected in Italy from<jats:italic>Aedes albopictus<\/jats:italic>mosquitoes, had already been isolated in Japan, the remaining five viruses have not been reported previously: one was detected in Italy, Portugal and Spain from<jats:italic>Aedes<\/jats:italic>mosquitoes (particularly from<jats:italic>Aedes caspius<\/jats:italic>), one in Portugal and Spain from<jats:italic>Culex theileri<\/jats:italic>mosquitoes, one in the Czech Republic and Italy from<jats:italic>Aedes vexans<\/jats:italic>, one in the Czech Republic from<jats:italic>Aedes vexans<\/jats:italic>and the last in the UK from<jats:italic>Aedes cinereus<\/jats:italic>. Phylogenetic analysis confirmed the close relationship of these putative viruses to other insect-only flaviviruses.<\/jats:p>","DOI":"10.1099\/vir.0.040485-0","type":"journal-article","created":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T04:51:11Z","timestamp":1330577471000},"page":"1215-1225","source":"Crossref","is-referenced-by-count":63,"title":["Detection of mosquito-only flaviviruses in Europe"],"prefix":"10.1099","volume":"93","author":[{"given":"Mattia","family":"Calzolari","sequence":"first","affiliation":[{"name":"Istituto Zooprofilattico Sperimentale della Lombardia e dell\u2019Emilia-Romagna \u2018B. 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