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We estimated the effects of<jats:italic>HLA<\/jats:italic>class I (A, B, and C), class II<jats:italic>DRB1<\/jats:italic>alleles, and the ancestral haplotype (AH) 8.1 (<jats:italic>HLA<\/jats:italic><jats:italic>A<jats:sup>*<\/jats:sup>01-B<jats:sup>*<\/jats:sup>08-DRB1<jats:sup>*<\/jats:sup>03-TNF-308A<\/jats:italic>) on overall survival (OS) among patients with diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) in a population-based study of non-Hodgkin lymphoma. During a median followup of 89 months, 31% (52 of 166) DLBCL and 28% (46 of 165) FL patients died. Using multivariate Cox regression models, we observed statistically significant associations between genetic variants and survival:<jats:italic>HLA-Cw<jats:sup>*<\/jats:sup>07:01<\/jats:italic>was associated with poorer OS among DLBCL patients (Hazard ratio [HR]\u2009=\u20091.76, 95% confidence interval [CI]\u2009=\u20091.01\u20133.05);<jats:italic>HLA-A<jats:sup>*<\/jats:sup>01:01<\/jats:italic>was associated with poorer OS (HR\u2009=\u20092.23, 95% CI\u2009=\u20091.24\u20134.01), and<jats:italic>HLA-DRB1<jats:sup>*<\/jats:sup>13<\/jats:italic>(HR\u2009=\u20090.12, 95% CI\u2009=\u20090.02\u20130.90) and<jats:italic>HLA-B Bw4<\/jats:italic>(HR\u2009=\u20090.36, 95% CI\u2009=\u20090.20\u20130.63) with better OS among FL patients. These results support a role for<jats:italic>HLA<\/jats:italic>in the prognosis of DLBCL and FL and represent a promising class of prognostic factors that warrants further evaluation.<\/jats:p>","DOI":"10.1100\/2011\/373876","type":"journal-article","created":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T16:00:23Z","timestamp":1320163223000},"page":"2062-2070","source":"Crossref","is-referenced-by-count":26,"title":["Human Leukocyte Antigen Class I and II Alleles and Overall Survival in Diffuse Large B-Cell Lymphoma and Follicular Lymphoma"],"prefix":"10.1100","volume":"11","author":[{"given":"Yani","family":"Lu","sequence":"first","affiliation":[{"name":"Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr M.","family":"Abdou","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, National Research 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