{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T05:18:46Z","timestamp":1720070326751},"reference-count":46,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Ministry of Education and Science of Serbia","award":["175092"],"award-info":[{"award-number":["175092"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World JOURNAL"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>The role of aristolochic acid in the etiology of Balkan endemic nephropathy (BEN) and associated upper-tract urothelial carcinoma (UTUC) has been recently confirmed. The aim of this study was to determine apoptosis-related marker(s) specific for BEN-associated UTUC. Present investigation included 105 patients with UTUC, 44 from BEN region and 61 control tumors. Altered expression of Survivin was more often present in BEN UTUC with high grade and solid growth (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.005<\/mml:mn><\/mml:math>;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>) than in control tumors. Significantly lower expression of proapoptotic marker Bax was found in BEN tumors with high grade, high stage, necrosis, and without metaplastic change (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>; 0.05; 0.05; 0.05) compared to control tumors with the same features. Group (BEN-related\/control), stage, growth pattern, and caspase 3 activity were significantly associated with the expression of Bax (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:math>, 0.034, 0.047, 0.028, resp.,). This investigation identifies Bax as specific marker of BEN-associated UTUC. Decrease of pro-apoptotic protein Bax together with alteration of Survivin may be indicative for specific disturbances of intrinsic apoptotic pathway in UTUC arising in endemic areas.<\/jats:p>","DOI":"10.1100\/2011\/752790","type":"journal-article","created":{"date-parts":[[2011,10,17]],"date-time":"2011-10-17T14:19:52Z","timestamp":1318861192000},"page":"1699-1711","source":"Crossref","is-referenced-by-count":5,"title":["Pro- and Antiapoptotic Markers in Upper Tract Urothelial Carcinoma Associated with Balkan Endemic Nephropathy"],"prefix":"10.1100","volume":"11","author":[{"given":"Ljubinka","family":"Jankovic-Velickovic","sequence":"first","affiliation":[{"name":"Institute of Pathology, Faculty of Medicine, University of Nis, 18000 Nis, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slavica","family":"Stojnev","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Faculty of Medicine, University of Nis, 18000 Nis, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Ristic-Petrovic","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Faculty of Medicine, University of Nis, 18000 Nis, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zana","family":"Dolicanin","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Faculty of Medicine, University of Nis, 18000 Nis, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2121, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Mukaisho","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2121, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariola","family":"Stojanovic","sequence":"additional","affiliation":[{"name":"Public Health Institute, Nis, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladisav","family":"Stefanovic","sequence":"additional","affiliation":[{"name":"Institute of Nephrology, Faculty of Medicine, University of Nis, Boulevard Dr Zoran Djindjic 81, 18000 Nis, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","first-page":"857","volume-title":"Balkan nephropathy.","year":"1992"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1159\/000213081"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007445120729"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1159\/000090705"},{"issue":"12","key":"5","first-page":"1273","volume":"91","year":"1969","journal-title":"Lijecnicki Vjesnik"},{"issue":"6","key":"6","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1038\/ki.1994.220","volume":"45","year":"1994","journal-title":"Kidney International"},{"issue":"4","key":"7","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1080\/02652038509373555","volume":"2","year":"1985","journal-title":"Food Additives and Contaminants"},{"issue":"34","key":"8","first-page":"S-9","volume":"40","year":"1991","journal-title":"Kidney International Supplements"},{"issue":"6","key":"9","first-page":"856","volume":"114","year":"1975","journal-title":"Journal of Urology"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/ncpuro1019"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.02.004"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701248104"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2009.162"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000143194.79287.a9"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(07)70002-5"},{"key":"16","first-page":"93","volume-title":"Tumors of the urinary system. 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