{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:53:15Z","timestamp":1783471995009,"version":"3.55.0"},"reference-count":38,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Pineal gland is a very important neuroendocrine organ with many physiological functions such as regulating circadian rhythm. Radiologically, the pineal gland volume is clinically important because it is usually difficult to distinguish small pineal tumors via magnetic resonance imaging (MRI). Although many studies have estimated the pineal gland volume using different techniques, to the best of our knowledge, there has so far been no stereological work done on this subject. The objective of the current paper was to determine the pineal gland volume using stereological methods and by the region of interest (ROI) on MRI. In this paper, the pineal gland volumes were calculated in a total of 62 subjects (36 females, 26 males) who were free of any pineal lesions or tumors. The mean \u00b1 SD pineal gland volumes of the point-counting, planimetry, and ROI groups were<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mn>99.55<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>51.34<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mn>102.69<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>40.39<\/mml:mn><\/mml:math>, and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mn>104.33<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>40.45<\/mml:mn><\/mml:math>\u2009mm<jats:sup>3<\/jats:sup>, respectively. No significant difference was found among the methods of calculating pineal gland volume (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). From these results, it can be concluded that each technique is an unbiased, efficient, and reliable method, ideally suitable for in vivo examination of MRI data for pineal gland volume estimation.<\/jats:p>","DOI":"10.1100\/2012\/123412","type":"journal-article","created":{"date-parts":[[2012,4,19]],"date-time":"2012-04-19T22:00:47Z","timestamp":1334872847000},"page":"1-9","source":"Crossref","is-referenced-by-count":20,"title":["Comparison of Three Methods for the Estimation of Pineal Gland Volume Using Magnetic Resonance Imaging"],"prefix":"10.1100","volume":"2012","author":[{"given":"Niyazi","family":"Acer","sequence":"first","affiliation":[{"name":"Department of Anatomy, School of Medicine, Erciyes University Kayseri, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet Turan","family":"Il\u0131ca","sequence":"additional","affiliation":[{"name":"Department of Radiology, G\u00fclhane Military Medical School, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet Tuncay","family":"Turgut","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ankara Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"\u00d6z\u00e7elik","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Medicine, Erciyes University Kayseri, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birdal","family":"Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[{"name":"Department of Emergency, Mu\u011fla State Hospital, Mu\u011fla, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Turgut","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, School of Medicine, Adnan Menderes University Ayd\u0131n, 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