{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:48:35Z","timestamp":1740142115678,"version":"3.37.3"},"reference-count":77,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100005888","name":"Medical University of Lodz","doi-asserted-by":"crossref","award":["503\/1-153-03\/503-01"],"award-info":[{"award-number":["503\/1-153-03\/503-01"]}],"id":[{"id":"10.13039\/501100005888","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>The local renin-angiotensin system is present in the pituitary. We investigated the effects of angiotensins on GH3 lactosomatotroph cells proliferation in vitro and the involvement of p44\/42 and p38 MAPK inhibitors in the growth-regulatory effects of angiotensins.<jats:italic>Materials and Methods<\/jats:italic>. Cell viability using the Mosmann method and proliferation by the measurement of BrdU incorporation during DNA synthesis were estimated.<jats:italic>Results<\/jats:italic>. Ang II and ang IV decreased the viability and proliferation of GH3 cells. Inhibitor of p44\/42 MAPK attenuated the effects of ang II on cell viability and proliferation but did not affect the ang 5-8-dependent actions. Inhibitor of p38 MAPK prevented the decrease in the number of GH3 cells in ang-II- and ang-IV-treated groups.<jats:italic>Conclusions<\/jats:italic>. The growth-inhibitory effect of ang II is possibly mediated by the p44\/42 MAPK. The p38 MAPK appears to mediate the inhibitory effects of both ang II and ang 5\u20138 upon cell survival.<\/jats:p>","DOI":"10.1100\/2012\/189290","type":"journal-article","created":{"date-parts":[[2012,4,25]],"date-time":"2012-04-25T00:31:27Z","timestamp":1335313887000},"page":"1-10","source":"Crossref","is-referenced-by-count":2,"title":["Angiotensins Inhibit Cell Growth in GH3 Lactosomatotroph Pituitary Tumor Cell Culture: A Possible Involvement of the p44\/42 and p38 MAPK Pathways"],"prefix":"10.1100","volume":"2012","author":[{"given":"Dorota","family":"Ptasinska-Wnuk","sequence":"first","affiliation":[{"name":"Department of Endocrinology, The County Hospital of Kutno, 52 Kosciuszki Street, 99-300 Kutno, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Lawnicka","sequence":"additional","affiliation":[{"name":"Department of Immunoendocrinology, Chair of Endocrinology, Medical University of Lodz, Dr. Sterling 3 Street, 91-425 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slawomir","family":"Mucha","sequence":"additional","affiliation":[{"name":"Clinic of Endocrinology, Medical University of Lodz, Dr. Sterling 3 Street, 91-425 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolanta","family":"Kunert-Radek","sequence":"additional","affiliation":[{"name":"Clinic of Endocrinology, Medical University of Lodz, Dr. Sterling 3 Street, 91-425 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Pawlikowski","sequence":"additional","affiliation":[{"name":"Department of Immunoendocrinology, Chair of Endocrinology, Medical University of Lodz, Dr. Sterling 3 Street, 91-425 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henryk","family":"Stepien","sequence":"additional","affiliation":[{"name":"Department of Immunoendocrinology, Chair of Endocrinology, Medical University of Lodz, Dr. Sterling 3 Street, 91-425 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"2","key":"1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1161\/01.HYP.17.2.139","volume":"17","year":"1991","journal-title":"Hypertension"},{"issue":"6","key":"2","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1161\/01.CIR.88.6.2849","volume":"88","year":"1993","journal-title":"Circulation"},{"issue":"2","key":"3","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1677\/joe.0.1640207","volume":"164","year":"2000","journal-title":"Journal of Endocrinology"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2011.09.010"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2011.07.001"},{"issue":"1","key":"6","first-page":"S225","volume":"10","year":"1999","journal-title":"Journal of the American Society of Nephrology"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2011.05.012"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1210\/en.142.3.1349"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2010.02165.x"},{"key":"10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/978-90-481-9060-7_6","volume":"690","year":"2010","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"11","first-page":"69","volume-title":"The renin-angiotensin system: current research progress in the pancreas","volume":"690, part 2","year":"2010"},{"issue":"4","key":"12","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1042\/bst0280435","volume":"28","year":"2000","journal-title":"Biochemical Society Transactions"},{"issue":"2","key":"13","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000469453","volume":"32","year":"1984","journal-title":"Enzyme"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000254833.85106.4d"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00036.2005"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00431.2010"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90541-W"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1210\/en.131.3.1174"},{"issue":"1-2","key":"19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3109\/07435809509030424","volume":"21","year":"1995","journal-title":"Endocrine Research"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00220.2004"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(90)90260-Y"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706037"},{"issue":"11","key":"23","first-page":"BR410","volume":"10","year":"2004","journal-title":"Medical Science Monitor"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1007\/s000180050307"},{"issue":"3","key":"25","first-page":"139","volume":"35","year":"2001","journal-title":"Endocrine Regulations"},{"issue":"4","key":"26","first-page":"341","volume":"39","year":"2001","journal-title":"Folia Histochemica et Cytobiologica"},{"issue":"4","key":"27","first-page":"L707","volume":"283","year":"2002","journal-title":"American Journal of Physiology"},{"issue":"4","key":"28","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1161\/01.HYP.36.4.511","volume":"36","year":"2000","journal-title":"Hypertension"},{"issue":"2","key":"29","first-page":"F278","volume":"286","year":"2004","journal-title":"American Journal of Physiology"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200103001-00006"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2007.07.001"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2011.07.002"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.157552"},{"issue":"13","key":"34","doi-asserted-by":"crossref","first-page":"5889","DOI":"10.1073\/pnas.90.13.5889","volume":"90","year":"1993","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-60761-795-2_1","volume":"661","year":"2010","journal-title":"Methods in Molecular Biology"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.14.8389"},{"issue":"3","key":"37","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1042\/bj3180729","volume":"318","year":"1996","journal-title":"Biochemical Journal"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.10.6146"},{"issue":"3","key":"39","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1161\/01.HYP.36.3.330","volume":"36","year":"2000","journal-title":"Hypertension"},{"issue":"8","key":"40","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1681\/ASN.V1181387","volume":"11","year":"2000","journal-title":"Journal of the American Society of Nephrology"},{"issue":"11","key":"41","first-page":"1139","volume":"2","year":"2003","journal-title":"Molecular cancer therapeutics"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02377-8"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.2102"},{"issue":"1","key":"44","first-page":"57","volume":"99","year":"2007","journal-title":"Journal of the National Medical Association"},{"issue":"3","key":"45","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1177\/002215549804600303","volume":"46","year":"1998","journal-title":"Journal of Histochemistry and Cytochemistry"},{"issue":"12","key":"46","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1177\/002215540004801212","volume":"48","year":"2000","journal-title":"Journal of Histochemistry and Cytochemistry"},{"issue":"3","key":"47","first-page":"173","volume":"44","year":"2006","journal-title":"Folia Histochemica et Cytobiologica"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1006\/frne.1993.1008"},{"key":"49","first-page":"371","volume-title":"Is estrogen-induced pituitary hyperplasia and hyperprolactinaemia mediated by angiotensin II?","volume":"26","year":"1995"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0935"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2007.05.006"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02326-4"},{"issue":"1","key":"53","first-page":"107","volume":"55","year":"2004","journal-title":"Journal of Physiology and Pharmacology"},{"issue":"6","key":"54","first-page":"397","volume":"24","year":"2003","journal-title":"Neuroendocrinology Letters"},{"issue":"2","key":"55","first-page":"643","volume":"252","year":"1990","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1080\/14756360701515541"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.03.056"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2005.02.005"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.06.109"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1448"},{"issue":"5","key":"61","first-page":"E769","volume":"272","year":"1997","journal-title":"American Journal of Physiology"},{"issue":"10","key":"62","doi-asserted-by":"crossref","first-page":"4174","DOI":"10.1210\/endo.136.10.7664634","volume":"136","year":"1995","journal-title":"Endocrinology"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod61.1.319"},{"issue":"3","key":"64","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1210\/endo.136.3.7867603","volume":"136","year":"1995","journal-title":"Endocrinology"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2006.12.008"},{"issue":"5","key":"66","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1161\/01.RES.79.5.1007","volume":"79","year":"1996","journal-title":"Circulation Research"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90068-N"},{"issue":"3","key":"68","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1128\/MCB.12.3.915","volume":"12","year":"1992","journal-title":"Molecular and Cellular Biology"},{"issue":"2","key":"69","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1042\/bj2880351","volume":"288","year":"1992","journal-title":"Biochemical Journal"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00154-8"},{"issue":"2","key":"71","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0092-8674(95)90401-8","volume":"80","year":"1995","journal-title":"Cell"},{"issue":"2","key":"72","first-page":"621","volume":"290","year":"1999","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.4.2161"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19980515)52:4<483::AID-JNR12>3.0.CO;2-4"},{"issue":"6","key":"75","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1095\/biolreprod62.6.1486","volume":"62","year":"2000","journal-title":"Biology of Reproduction"},{"issue":"10","key":"76","first-page":"4930","volume":"158","year":"1997","journal-title":"Journal of Immunology"},{"issue":"1","key":"77","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1161\/01.HYP.31.1.152","volume":"31","year":"1998","journal-title":"Hypertension"}],"container-title":["The Scientific World Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2012\/189290.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2012\/189290.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2012\/189290.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T02:53:39Z","timestamp":1642128819000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/tswj\/2012\/189290\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":77,"alternative-id":["189290","189290"],"URL":"https:\/\/doi.org\/10.1100\/2012\/189290","relation":{},"ISSN":["1537-744X"],"issn-type":[{"type":"electronic","value":"1537-744X"}],"subject":[],"published":{"date-parts":[[2012]]}}}