{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:52:22Z","timestamp":1765975942461},"reference-count":38,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Lentinus edodes<\/jats:italic>is the medicinal macrofungus showing potential for therapeutic applications in infectious disorders including hepatitis. In an attempt to develop the agent for handling hepatic injury, we used the extracts of<jats:italic>Lentinus edodes<\/jats:italic>mycelia (LEM) to screen the effect on hepatic injury in rats induced by carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>). Intraperitoneal administration of CCl<jats:sub>4<\/jats:sub>not only increased plasma glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) but also decreased hepatic superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels in rats. Similar to the positive control silymarin, oral administration (three times daily) of this product (LEM) for 8 weeks significantly reduced plasma GOT and GPT. Also, the activities of antioxidant enzymes of SOD and GPx were elevated by LEM. in liver from CCl<jats:sub>4<\/jats:sub>-treated rats, indicating that mycelium can increase antioxidant-like activity. Moreover, the hepatic mRNA and protein levels of SOD and GPx were both markedly raised by LEM. The obtained results suggest that oral administration of the extracts of<jats:italic>Lentinus edodes<\/jats:italic>mycelia (LEM) has the protective effect against CCl<jats:sub>4<\/jats:sub>-induced hepatic injury in rats, mainly due to an increase in antioxidant-like action.<\/jats:p>","DOI":"10.1100\/2012\/231586","type":"journal-article","created":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T07:11:45Z","timestamp":1338275505000},"page":"1-8","source":"Crossref","is-referenced-by-count":4,"title":["Protection of the Extracts of<i>Lentinus edodes<\/i>Mycelia against Carbon-Tetrachloride-Induced Hepatic Injury in Rats"],"prefix":"10.1100","volume":"2012","author":[{"given":"Mei-Fen","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Nursing and Department of Biological Science and Technology, Chung Hwa University of Medical Technology, Jen-Te, Tainan City 71703, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsien-Hui","family":"Chung","sequence":"additional","affiliation":[{"name":"Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan City 70101, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han-Lin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Nursing and Department of Biological Science and Technology, Chung Hwa University of Medical Technology, Jen-Te, Tainan City 71703, Taiwan"},{"name":"Department of Chinese Medicine, St. Joseph Hospital, Lin-Yah, Kaohsiung City 80288, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i20.2507"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017484"},{"issue":"5","key":"3","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.fct.2012.01.016","volume":"50","year":"2012","journal-title":"Food and Chemical Toxicology"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i1.111"},{"issue":"3","key":"5","first-page":"363","volume":"43","year":"2010","journal-title":"Biological Research"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9956"},{"issue":"9","key":"7","first-page":"896","volume":"48","year":"2010","journal-title":"Indian Journal of Experimental Biology"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X10008329"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.3086"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.2174\/092986710791698495"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-009-0357-1"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.27.1957"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.29.1651"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-011-0510-8"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1002\/jat.2550100408"},{"issue":"2","key":"16","first-page":"479","volume":"54","year":"1990","journal-title":"Agricultural and Biological Chemistry"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2006.03.009"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020822610085"},{"key":"19","first-page":"472","volume":"90","year":"1989","journal-title":"Indian Journal of Medical Research B"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.12.011"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3121"},{"issue":"4","key":"22","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/10715760100300321","volume":"34","year":"2001","journal-title":"Free Radical Research"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/703676"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2011.04.043"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2146"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2210-5-2"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.3390\/ijms12053117"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2007.01463.x"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2005.8.261"},{"issue":"1","key":"30","first-page":"363","volume":"23","year":"2003","journal-title":"Anticancer Research A"},{"issue":"2-3","key":"31","first-page":"49","volume":"28","year":"2002","journal-title":"Drugs under Experimental and Clinical Research"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00490.x"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.32.1215"},{"issue":"3","key":"34","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/BF00164536","volume":"33","year":"1990","journal-title":"Applied Microbiology and Biotechnology"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.33.983"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X11008956"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.2131\/jts.35.785"},{"issue":"3","key":"38","doi-asserted-by":"crossref","first-page":"149","DOI":"10.5551\/jat.9.149","volume":"9","year":"2002","journal-title":"Journal of Atherosclerosis and Thrombosis"}],"container-title":["The Scientific World Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2012\/231586.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2012\/231586.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2012\/231586.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T19:23:12Z","timestamp":1497986592000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/tswj\/2012\/231586\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":38,"alternative-id":["231586","231586"],"URL":"https:\/\/doi.org\/10.1100\/2012\/231586","relation":{},"ISSN":["1537-744X"],"issn-type":[{"value":"1537-744X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}