{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T11:24:21Z","timestamp":1774783461975,"version":"3.50.1"},"reference-count":16,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>The resistance to antimicrobial agents brings a need of novel antimicrobial agents. We have synthesized and found the<jats:italic>in vitro<\/jats:italic>antibacterial activity of salicylanilide esters with benzoic acid (2-(phenylcarbamoyl)phenyl benzoates) in micromolar range. They were evaluated<jats:italic>in vitro<\/jats:italic>for the activity against eight fungal and eight bacterial species. All derivatives showed a significant antibacterial activity against Gram-positive strains with minimum inhibitory concentrations \u22650.98\u2009\u03bcmol\/L including methicillin-resistant<jats:italic>Staphylococcus aureus<\/jats:italic>strain. The most active compounds were 5-chloro-2-(3,4-dichlorophenylcarbamoyl)phenyl benzoate and 4-chloro-2-(4-(trifluoromethyl)phenylcarbamoyl)phenyl benzoate. The antifungal activity is significantly lower.<\/jats:p>","DOI":"10.1100\/2012\/290628","type":"journal-article","created":{"date-parts":[[2012,4,30]],"date-time":"2012-04-30T22:02:12Z","timestamp":1335823332000},"page":"1-7","source":"Crossref","is-referenced-by-count":14,"title":["<i>In Vitro<\/i>Antibacterial and Antifungal Activity of Salicylanilide Benzoates"],"prefix":"10.1100","volume":"2012","author":[{"given":"Martin","family":"Kr\u00e1tk\u00fd","sequence":"first","affiliation":[{"name":"Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Heyrovsk\u00e9ho 1203, 500 05 Hradec Kr\u00e1lov\u00e9, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarmila","family":"Vin\u0161ov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Heyrovsk\u00e9ho 1203, 500 05 Hradec Kr\u00e1lov\u00e9, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladim\u00edr","family":"Buchta","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Faculty of Medicine and University Hospital, Charles University, Sokolsk\u00e1 581, 500 12 Hradec Kr\u00e1lov\u00e9, Czech Republic"},{"name":"Department of Biological and Medical Sciences, Faculty of Pharmacy, Charles University, Heyrovsk\u00e9ho 1203, 500 05 Hradec Kr\u00e1lov\u00e9, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(09)70549-7"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2010.04.004"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2009.08.002"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2011.141"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3390\/12010001"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.11.080"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.09.040"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2010.10.036"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-827150"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.31.1301"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.12.006"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1021\/jf020088v"},{"issue":"11","key":"13","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1271\/bbb.62.2273","volume":"62","year":"1998","journal-title":"Bioscience, Biotechnology, and Biochemistry"},{"issue":"2","key":"14","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1271\/bbb.58.293","volume":"58","year":"1994","journal-title":"Bioscience, Biotechnology, and Biochemistry"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2009.02.058"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1605(99)00072-0"}],"container-title":["The Scientific World Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2012\/290628.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2012\/290628.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2012\/290628.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T18:06:07Z","timestamp":1497981967000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/tswj\/2012\/290628\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":16,"alternative-id":["290628","290628"],"URL":"https:\/\/doi.org\/10.1100\/2012\/290628","relation":{},"ISSN":["1537-744X"],"issn-type":[{"value":"1537-744X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}