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We classified 304 subjects without cardiovascular disease into 4 groups according to the total number of RFs (smoking, hypertension, hypercholesterolaemia, hyperhomocysteinaemia, diabetes, obesity, and their combination). Oxidative stress was evaluated by measuring plasma total and reduced homocysteine, cysteine (Cys), glutathione, cysteinylglycine, blood reduced glutathione, and malondialdehyde. Twenty-seven percent of subjects were in group 0 RF, 26% in 1 RF, 31% in 2 RF, and 16% in \u22653 RF. By multivariable ordinal regression analysis, plasma total Cys was associated to a higher number of RF (OR = 1.068; 95% CI = 1.027\u20131.110, ). Total RF burden is associated with increased total Cys levels. These findings support a prooxidant effect of Cys in conjunction with RF burden, and shed light on the pathophysiologic role of redox state unbalance in preclinical atherosclerosis.<\/jats:p>","DOI":"10.1100\/2012\/303654","type":"journal-article","created":{"date-parts":[[2012,4,19]],"date-time":"2012-04-19T18:03:05Z","timestamp":1334858585000},"page":"1-7","source":"Crossref","is-referenced-by-count":18,"title":["Plasma Total Cysteine and Cardiovascular Risk Burden: Action and Interaction"],"prefix":"10.1100","volume":"2012","author":[{"given":"Benedetta","family":"De Chiara","sequence":"first","affiliation":[{"name":"CNR Clinical Physiology Institute and Cardiovascular Department, Niguarda Ca' Granda Hospital, 20162 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Sedda","sequence":"additional","affiliation":[{"name":"CNR Clinical Physiology Institute and Cardiovascular Department, Niguarda Ca' Granda Hospital, 20162 Milan, 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