{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:10:28Z","timestamp":1787314228067,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Dokuz Eylul University Research Foundation","award":["2012.KB.SAG.060"],"award-info":[{"award-number":["2012.KB.SAG.060"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>\n                    Testicular torsion is one of the urologic emergencies occurring frequently in neonatal and adolescent period. Testis is sensitive to ischemia-reperfusion injury, and, therefore, ischemia and consecutive reperfusion cause an enhanced formation of reactive oxygen species that result in testicular cell damage and apoptosis.\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -lipoic acid is a free radical scavenger and a biological antioxidant. It is widely used in the prevention of oxidative stress and cellular damage. We aimed to investigate the protective effect of\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -lipoic acid on testicular damage in rats subjected to testicular ischemia-reperfusion injury. 35 rats were randomly divided into 5 groups: control, sham operated, ischemia, ischemia-reperfusion, and ischemia-reperfusion +lipoic acid groups, 2\u2009h torsion and 2\u2009h detorsion of the testis were performed. Testicular cell damage was examined by H-E staining. TUNEL and active caspase-3 immunostaining were used to detect germ cell apoptosis. GPx , SOD activity, and MDA levels were evaluated. Histological evaluation showed that\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -lipoic acid pretreatment reduced testicular cell damage and decreased TUNEL and caspase-3-positive cells. Additionally,\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -lipoic acid administration decreased the GPx and SOD activity and increased the MDA levels. The present results suggest that LA is a potentially beneficial agent in protecting testicular I\/R in rats.\n                  <\/jats:p>","DOI":"10.1100\/2012\/489248","type":"journal-article","created":{"date-parts":[[2012,10,24]],"date-time":"2012-10-24T17:01:17Z","timestamp":1351098077000},"page":"1-8","source":"Crossref","is-referenced-by-count":59,"title":["The Effects of\n                    <i>\u03b1<\/i>\n                    -Lipoic Acid against Testicular Ischemia-Reperfusion Injury in Rats"],"prefix":"10.1100","volume":"2012","author":[{"given":"Seda","family":"Ozbal","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology, School of Medicine, Dokuz Eyl\u00fcl University Inciralti, 35340 \u0130zmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bekir Ugur","family":"Ergur","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, School of Medicine, Dokuz Eyl\u00fcl University Inciralti, 35340 \u0130zmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guven","family":"Erbil","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, School of Medicine, Dokuz Eyl\u00fcl University Inciralti, 35340 \u0130zmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Is\u0131l","family":"Tekmen","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, School of Medicine, Dokuz Eyl\u00fcl University Inciralti, 35340 \u0130zmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alper","family":"Bagr\u0131yan\u0131k","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, School of Medicine, Dokuz Eyl\u00fcl University Inciralti, 35340 \u0130zmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahide","family":"Cavdar","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, 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