{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:16:22Z","timestamp":1792163782703,"version":"4.4.0"},"reference-count":13,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Aims and Method<\/jats:italic>. To evaluate the practical utility of off-licence prescribing and clinical outcomes of treatment with atypical antipsychotic Melperone.<jats:italic>Method<\/jats:italic>: Prospective data collection on patient\u2019s clinical characteristics and outcomes.<jats:italic>Results<\/jats:italic>. 17 patients with a diagnosis of refractory schizophrenia were identified as suitable for off-license prescribing of Melperone and commenced treatment (13 were previously treated with Clozapine). Seven of those currently remain on Melperone (41%), and for six patents, the BPRS symptom scores reduced significantly over time (24\u201361%) additionally patients displayed improvements of their quality of life. Six patients were discontinued due to noncompliance and\/or side effects. Melperone was ineffective in the other four patients.<jats:italic>Clinical Implications<\/jats:italic>. The example of a small group of patients responding well to a comparably safe and inexpensive atypical antipsychotic with favourable side effect profile should encourage clinicians to use this tool as third-line treatment and to conduct more systematic clinical research.<\/jats:p>","DOI":"10.1100\/2012\/512047","type":"journal-article","created":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T22:01:55Z","timestamp":1333317715000},"page":"1-5","source":"Crossref","is-referenced-by-count":5,"title":["Auditing Clinical Outcomes after Introducing Off-Licence Prescribing of Atypical Antipsychotic Melperone for Patients with Treatment Refractory Schizophrenia"],"prefix":"10.1100","volume":"2012","author":[{"given":"Frank","family":"R\u00f6hricht","sequence":"first","affiliation":[{"name":"Newham Centre for Mental Health, East London NHS Foundation Trust and University of Essex, London E13 8SP, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Gadhia","sequence":"additional","affiliation":[{"name":"Buckinghamshire NHS Primary Care Trust, Community Pharmacy, Aylesbury HP19 8ET, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinku","family":"Alam","sequence":"additional","affiliation":[{"name":"North East London NHS Foundation Trust, General Adult Psychiatry, Ilford, Essex IG3 8XJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Willis","sequence":"additional","affiliation":[{"name":"Kent and Medway NHS and Social Care Partnership Trust, Kent ME19 4AX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1192\/apt.11.2.101"},{"issue":"4","key":"2","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1093\/schbul\/23.4.663","volume":"23","year":"1997","journal-title":"Schizophrenia Bulletin"},{"issue":"9","key":"4","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1001\/archpsyc.1988.01800330013001","volume":"45","year":"1988","journal-title":"Archives of General Psychiatry"},{"issue":"7","key":"5","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1176\/ajp.156.7.990","volume":"156","year":"1999","journal-title":"American Journal of Psychiatry"},{"issue":"352","key":"7","first-page":"30","volume":"80","year":"1989","journal-title":"Acta Psychiatrica Scandinavica, Supplement"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/hup.1036"},{"issue":"4","key":"9","first-page":"201","volume":"11","year":"1996","journal-title":"Functional Neurology"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2009.03.026"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/S0379-0738(00)00201-2"},{"issue":"352","key":"12","first-page":"35","volume":"80","year":"1989","journal-title":"Acta Psychiatrica Scandinavica, Supplement"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(01)00346-8"},{"key":"14","first-page":"227","volume":"3","year":"1993","journal-title":"International Journal of Methods in Psychiatric Research"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(02)00351-1"}],"container-title":["The Scientific World Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2012\/512047.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2012\/512047.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2012\/512047.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T14:40:00Z","timestamp":1713796800000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/tswj\/2012\/512047\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":13,"alternative-id":["512047","512047"],"URL":"https:\/\/doi.org\/10.1100\/2012\/512047","relation":{},"ISSN":["1537-744X"],"issn-type":[{"value":"1537-744X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}