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In the first phase of this study,<jats:italic>S. mansoni<\/jats:italic>-infected mice were treated, orally, with 100\u2009mg\/Kg of the LPSF-PT05 in three formulations: Tween 80 and saline solution, oil\/water (70\u2009:\u200930) emulsion, and solid dispersion with polyethylene glycol (PEG). In the second phase, three other doses of the LPSF-PT05 in PEG were tested: 3, 10, 30\u2009mg\/kg. These treatment regimens significantly reduced the number of recovered worms due to increases in the solubility of the compound in this formulation; the greatest reduction (70.5%) was observed at the dose of 100\u2009mg\/kg. There was no changes in the pattern of mature egg compared to immature eggs; however there was a significant increase in the number of dead eggs. Histopathological analysis of liver tissue showed changes in morphological aspects of the hepatic parenchyma with decrease exudative-productive hepatic granuloma stages, although we found no significant differences in IFN-<jats:italic>\u03b3<\/jats:italic>, IL-4, IL-10, or NO production in response to the specific antigen SEA. The results show the derivative LPSF-PT05 to be a potential candidate in the etiological treatment of schistosomiasis with a possible dampening effect of the granulomatous process.<\/jats:p>","DOI":"10.1100\/2012\/520524","type":"journal-article","created":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T22:02:39Z","timestamp":1335909759000},"page":"1-8","source":"Crossref","is-referenced-by-count":4,"title":["Study of the Activity of 3-benzyl-5-(4-chloro-arylazo)-4-thioxo-imidazolidin-2-one against Schistosomiasis Mansoni in Mice"],"prefix":"10.1100","volume":"2012","author":[{"given":"Andr\u00e9a Cristina Apolin\u00e1rio","family":"da Silva","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Planejamento e S\u00edntese de F\u00e1rmacos (LPSF), Universidade Federal de Pernambuco, Avenida Profssors Moraes Rego 1265, Cidade Universit\u00e1ria, 50670-901 Recife, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Kelle de Andrade 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