{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:51:54Z","timestamp":1791042714504,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Dengue fever is a noncontagious infectious disease caused by dengue virus (DENV). DENV belongs to the family<jats:italic>Flaviviridae<\/jats:italic>, genus<jats:italic>Flavivirus<\/jats:italic>, and is classified into four antigenically distinct serotypes: DENV-1, DENV-2, DENV-3, and DENV-4. The number of nations and people affected has increased steadily and today is considered the most widely spread arbovirus (arthropod-borne viral disease) in the world. The absence of an appropriate animal model for studying the disease has hindered the understanding of dengue pathogenesis. In our study, we have found that immunocompetent C57BL\/6 mice infected intraperitoneally with DENV-1 presented some signs of dengue disease such as thrombocytopenia, spleen hemorrhage, liver damage, and increase in production of IFN<jats:italic>\u03b3<\/jats:italic>and TNF<jats:italic>\u03b1<\/jats:italic>cytokines. Moreover, the animals became viremic and the virus was detected in several organs by real-time RT-PCR. Thus, this animal model could be used to study mechanism of dengue virus infection, to test antiviral drugs, as well as to evaluate candidate vaccines.<\/jats:p>","DOI":"10.1100\/2012\/525947","type":"journal-article","created":{"date-parts":[[2012,5,17]],"date-time":"2012-05-17T12:25:10Z","timestamp":1337257510000},"page":"1-12","source":"Crossref","is-referenced-by-count":22,"title":["Imunocompetent Mice Model for Dengue Virus Infection"],"prefix":"10.1100","volume":"2012","author":[{"given":"Denise","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas, Toxicol\u00f3gicas e Bromatol\u00f3gicas da Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Avenida Bandeirantes 3900, Monte Alegre, 14049-900 Ribeirao Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"de Queiroz Prado","sequence":"additional","affiliation":[{"name":"Centro de Pesquisa em Virologia da Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Avenida Bandeirantes 3900, Monte Alegre, 14049-900 Ribeirao Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Almeida Xavier","sequence":"additional","affiliation":[{"name":"Centro de Pesquisa em Virologia da Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Avenida Bandeirantes 3900, Monte Alegre, 14049-900 Ribeirao Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia","family":"Cristina de Oliveira","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas, Toxicol\u00f3gicas e Bromatol\u00f3gicas da Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Avenida Bandeirantes 3900, Monte Alegre, 14049-900 Ribeirao Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Marcos","family":"da Matta Guedes","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia e Parasitologia, Universidade Federal do Rio Grande do Norte, Avenida Salgado Filho SN, Campus Universit\u00e1rio, 59078-900 Natal, RN, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Santana","family":"da Silva","sequence":"additional","affiliation":[{"name":"Departamento de Parasitologia, Microbiologia e Imunologia da Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Avenida Bandeirantes 3900, Monte Alegre, 14049-900 Ribeirao Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Tadeu","family":"Moraes Figueiredo","sequence":"additional","affiliation":[{"name":"Centro de Pesquisa em Virologia da Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Avenida Bandeirantes 3900, Monte Alegre, 14049-900 Ribeirao Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Hugo","family":"Aquino","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas, Toxicol\u00f3gicas e Bromatol\u00f3gicas da Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Avenida Bandeirantes 3900, Monte Alegre, 14049-900 Ribeirao Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"1","key":"1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4269\/ajtmh.1952.1.30","volume":"1","year":"1952","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.4049\/jimmunol.73.5.363","volume":"73","year":"1954","journal-title":"The Journal of Immunology"},{"issue":"1","key":"3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/oxfordjournals.aje.a121372","volume":"95","year":"1972","journal-title":"American Journal of Epidemiology"},{"key":"4","year":"2009"},{"issue":"3","key":"5","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1128\/CMR.11.3.480","volume":"11","year":"1998","journal-title":"Clinical Microbiology Reviews"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20108"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02575-06"},{"issue":"9","key":"8","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1099\/0022-1317-81-9-2177","volume":"81","year":"2000","journal-title":"Journal of General Virology"},{"issue":"3","key":"9","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.4049\/jimmunol.177.3.1855","volume":"177","year":"2006","journal-title":"The Journal of Immunology"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00062-06"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.21.13797-13799.2005"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2007.06.005"},{"issue":"6","key":"13","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1152\/jappl.1950.3.6.365","volume":"3","year":"1950","journal-title":"Journal of Applied Physiology"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/nature07013"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1038\/77553"},{"key":"16","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.0022-202x.2001.00037.x","volume":"6","year":"2001","journal-title":"Journal of Investigative Dermatology Symposium Proceedings"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.8.3501-3508.2001"},{"issue":"3","key":"18","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.4049\/jimmunol.166.3.1499","volume":"166","year":"2001","journal-title":"The Journal of Immunology"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/0928-0197(94)00032-P"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90230-7"},{"issue":"4","key":"21","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1590\/S1413-86702005000400012","volume":"9","year":"2005","journal-title":"Brazilian Journal of Infectious Diseases"},{"issue":"3","key":"22","doi-asserted-by":"crossref","first-page":"416","DOI":"10.4269\/ajtmh.2009.80.416","volume":"80","year":"2009","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1086\/383043"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/S1201-9712(99)90033-4"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/0166-0934(93)90121-7"},{"issue":"4","key":"26","first-page":"204","volume":"16","year":"1997","journal-title":"Clinical Neuropathology"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2005.10.007"},{"issue":"4","key":"28","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1590\/S1413-86702007000400007","volume":"11","year":"2007","journal-title":"Brazilian Journal of Infectious Diseases"},{"issue":"3","key":"29","doi-asserted-by":"crossref","first-page":"265","DOI":"10.4269\/ajtmh.1992.47.265","volume":"47","year":"1992","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"issue":"2","key":"30","first-page":"156","volume":"8","year":"2004","journal-title":"Brazilian Journal of Infectious Diseases"},{"issue":"2","key":"31","first-page":"259","volume":"31","year":"2000","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.6.864"},{"issue":"2","key":"33","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s004280000329","volume":"438","year":"2001","journal-title":"Virchows Archiv"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1999.9887"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1086\/518007"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2010.07.007"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.04.042"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2001.1114"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.11.4957-4966.2000"},{"issue":"8","key":"40","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1099\/0022-1317-67-8-1653","volume":"67","year":"1986","journal-title":"Journal of General Virology"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.6.2701-2710.2004"},{"issue":"3","key":"42","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1086\/517807","volume":"177","year":"1998","journal-title":"Journal of Infectious Diseases"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1086\/314680"},{"key":"44","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.1348-0421.1996.tb01110.x","volume":"40","year":"1996","journal-title":"Microbiology and Immunology"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00968-08"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-8244(00)00163-2"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00711.x"}],"updated-by":[{"DOI":"10.1155\/2018\/5268929","type":"corrigendum","label":"Corrigendum","source":"publisher","updated":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T00:00:00Z","timestamp":1536192000000}}],"container-title":["The Scientific World Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2012\/525947.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2012\/525947.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2012\/525947.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T20:05:00Z","timestamp":1687464300000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/tswj\/2012\/525947\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":47,"alternative-id":["525947","525947"],"URL":"https:\/\/doi.org\/10.1100\/2012\/525947","relation":{"corrigendum":[{"id-type":"doi","id":"10.1155\/2018\/5268929","asserted-by":"object"}]},"ISSN":["1537-744X"],"issn-type":[{"value":"1537-744X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}