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Considering that the continuous wave CO<jats:sub>2<\/jats:sub>laser delivery system and the newer \u201csuperpulsed\u201d and scanned CO<jats:sub>2<\/jats:sub>systems have progressively changed our practice and patient satisfaction, a long range documentation can be useful. Our experience has demonstrated that the use of CO<jats:sub>2<\/jats:sub>laser involves a reduced healing time, an infrequent need for anaesthesia, reduced thermal damage, less bleeding, less inflammation, the possibility of intra-operative histologic and\/or cytologic examination, and easy access to anatomically difficult areas. Immediate side effects have been pain, erythema, edema, typically see with older methods, using higher power. The percentage of after-treatment keloids and hypertrophic scars observed was very low (~1%) especially upon the usage of lower parameters. The recurrence of viral lesions (condylomas and warts) have been not more frequent than those due to other techniques. Tumor recurrence is minor compared with radiotherapy or surgery. This method is a valid alternative to surgery and\/or diathermocoagulation for microsurgery of soft tissues. Our results are at times not consistent with those published in the literature, stressing the concept that multicentric studies that harmonization methodology and the patient selection are vital.<\/jats:p>","DOI":"10.1100\/2012\/546528","type":"journal-article","created":{"date-parts":[[2012,4,19]],"date-time":"2012-04-19T22:03:51Z","timestamp":1334873031000},"page":"1-11","source":"Crossref","is-referenced-by-count":27,"title":["Highlights of Thirty-Year Experience of Laser Use at the Florence (Italy) Department of Dermatology"],"prefix":"10.1100","volume":"2012","author":[{"given":"Piero","family":"Campolmi","sequence":"first","affiliation":[{"name":"Section of Clinical, Preventive and Oncologic Dermatology, Department of Critical Care Medicine and Surgery, University of Florence, Villa S.Chiara, Piazza Indipendenza 11, 50129 Florence, 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