{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:40:20Z","timestamp":1758400820004},"reference-count":47,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Worldwide<jats:italic>Schistosomiasis mansoni<\/jats:italic>continues to be a serious public health problem. Over the past decades, control programmes have made remarkable progress in reducing<jats:italic>S. mansoni<\/jats:italic>infections to a relatively low level in Brazil and African countries. Endemic regions are currently circumscribed in certain core areas where reinfection and repeated chemotherapy are frequent and, consequently, are related to residents with low parasite load. At present, diagnosis is predominately a key step for final disease control although low endemicity area residents are hardly detected by most of the available assays. In this paper, we review the current status and efforts made aiming at the improvement of diagnostic tools for<jats:italic>S. mansoni<\/jats:italic>in low endemicity infections. The establishment of diagnostic assays\u2014simple, affordable, sensitive, and specific for field diagnosis of<jats:italic>S. mansoni<\/jats:italic>\u2014is essential and should be given high priority.<\/jats:p>","DOI":"10.1100\/2012\/593947","type":"journal-article","created":{"date-parts":[[2012,12,17]],"date-time":"2012-12-17T16:21:14Z","timestamp":1355761274000},"page":"1-5","source":"Crossref","is-referenced-by-count":5,"title":["Immunodiagnostic Methods: What Is Their Role in Areas of Low Endemicity?"],"prefix":"10.1100","volume":"2012","author":[{"given":"Rafaella Fortini Queiroz","family":"Grenfell","sequence":"first","affiliation":[{"name":"Schistosomiasis Laboratory, Rene Rachou Research Center, Oswaldo Cruz Foundation (Fiocruz), Avenida Augusto de Lima, 1715\/201 Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Silva-Moraes","sequence":"additional","affiliation":[{"name":"Schistosomiasis Laboratory, Rene Rachou 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