{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T11:46:27Z","timestamp":1768909587878,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81070953"],"award-info":[{"award-number":["81070953"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2011WK3002"],"award-info":[{"award-number":["2011WK3002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002767","name":"Hunan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["81070953"],"award-info":[{"award-number":["81070953"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002767","name":"Hunan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["2011WK3002"],"award-info":[{"award-number":["2011WK3002"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Lennox-Gastaut syndrome (LGS) is a devastating and refractory generalized epilepsy affecting children and adolescents. In this study we report the results of resective surgery in 18 patients with LGS phenotype who underwent single-lobe\/lesionectomy or multilobe resection plus multiple subpial transection and\/or callosotomy. After surgery, seven patients became completely seizure-free (Engel Class I) and five almost seizure-free (Engel Class II). Additional four had significant seizure control (Engel Class III), and two had no change in seizure frequency (Engel Class IV). Of the 4 patients without any lesion on brain MRI, 2 ended with Engel Class II, 1 with III and the other with IV in Engels\u2019 classification. Mean intelligence quotient (IQ) increased from 56.1\u2009\u00b1\u20098.1 (mean\u2009\u00b1\u2009SD) before operation to 67.4\u2009\u00b1\u20098.2 (mean\u2009\u00b1\u2009SD) after operation, a significant improvement (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>). Results also indicated that the younger the patient at surgery, or the shorter the interval between onset of seizure and resective operation, the better the intellectual outcome. Our data suggest that resective epilepsy surgery can be successful in patients with LGS phenotype as long as the EEG shows dominance of discharges in one hemisphere and corresponding ipsilateral imaging findings, even with contralateral ictal discharges.<\/jats:p>","DOI":"10.1100\/2012\/614263","type":"journal-article","created":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T18:03:53Z","timestamp":1335895433000},"page":"1-10","source":"Crossref","is-referenced-by-count":20,"title":["Surgical Treatment of Patients with Lennox-Gastaut Syndrome Phenotype"],"prefix":"10.1100","volume":"2012","author":[{"given":"Shi-Yong","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"An","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabhdeep","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Oommen","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Hua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Qing","family":"Gao","sequence":"additional","affiliation":[{"name":"Research Center for Medical Sciences of The 3rd XiangYa Hospital, and The Center for Scientific Research with Animal Models, 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