{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:35:27Z","timestamp":1782797727809,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Orthodontic treatment has been shown to induce inflammation, followed by bone remodelling in the periodontium. These processes trigger the secretion of various proteins and enzymes into the saliva. This study aims to identify salivary proteins that change in expression during orthodontic tooth movement. These differentially expressed proteins can potentially serve as protein biomarkers for the monitoring of orthodontic treatment and tooth movement. Whole saliva from three healthy female subjects were collected before force application using fixed appliance and at 14 days after 0.014\u2032\u2032 Niti wire was applied. Salivary proteins were resolved using two-dimensional gel electrophoresis (2DE) over a pH range of 3\u201310, and the resulting proteome profiles were compared. Differentially expressed protein spots were then identified by MALDI-TOF\/TOF tandem mass spectrometry. Nine proteins were found to be differentially expressed; however, only eight were identified by MALDI-TOF\/TOF. Four of these proteins\u2014Protein S100-A9, immunoglobulin J chain, Ig alpha-1 chain C region, and CRISP-3\u2014have known roles in inflammation and bone resorption.<\/jats:p>","DOI":"10.1100\/2012\/647240","type":"journal-article","created":{"date-parts":[[2012,7,31]],"date-time":"2012-07-31T18:01:48Z","timestamp":1343757708000},"page":"1-6","source":"Crossref","is-referenced-by-count":34,"title":["Proteomic Analysis of Saliva Identifies Potential Biomarkers for Orthodontic Tooth Movement"],"prefix":"10.1100","volume":"2012","author":[{"given":"Mohd Faiz","family":"Ellias","sequence":"first","affiliation":[{"name":"School of Bioscience and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Selangor, 43600 Bangi, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahrul Hisham","family":"Zainal Ariffin","sequence":"additional","affiliation":[{"name":"School of Bioscience and Biotechnology, Faculty of Science and Technology, 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