{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T02:11:32Z","timestamp":1773799892712,"version":"3.50.1"},"reference-count":25,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>The purpose of this study is to investigate the bioavailability and glycaemic metabolism of cinnamon oil (CIO) carried by liquid-loadable tablets (CIO-LLTs), the carrier of a CIO self-emulsifying formulation (CIO-LS). The results of tests performed to evaluate the physical properties of the CIO-LLT complied with Chinese Pharmacopeia (2010). The release profile suggested that the CIO-LLT preserved the enhancement of in vitro dissolution of cio. After orally administration, the plasma concentration-time profile and pharmacokinetic parameters suggested that a significant increase (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.0001<\/mml:mn><\/mml:math>) in the<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:msub><mml:mrow><mml:mi>C<\/mml:mi><\/mml:mrow><mml:mrow><mml:mtext>max<\/mml:mtext><\/mml:mrow><\/mml:msub><\/mml:math>, AUC and<jats:italic>F<\/jats:italic>were observed in the CIO-LLT. The blood glucose and the HbA1c were significantly decreased in alloxan-induced hyperglycemic rats (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>, resp.), while the level of insulin secretion was markedly elevated in alloxan-induced hyperglycemic rats (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). The alloxan-damaged pancreatic<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>\u03b2<\/mml:mi><\/mml:math>-cells of the rats were partly recovered gradually after the rats were administered with CIO-LLT 45 days later. CIO-LLT could improve the bioavailability and glycaemic metabolism of CIO.<\/jats:p>","DOI":"10.1100\/2012\/681534","type":"journal-article","created":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T22:02:02Z","timestamp":1333317722000},"page":"1-6","source":"Crossref","is-referenced-by-count":5,"title":["Improvement of the Bioavailability and Glycaemic Metabolism of Cinnamon Oil in Rats by Liquid Loadable Tablets"],"prefix":"10.1100","volume":"2012","author":[{"given":"Chunchao","family":"Han","sequence":"first","affiliation":[{"name":"School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Cui","sequence":"additional","affiliation":[{"name":"College of Food and Biological Engineering, Shandong Polytechnic University, Jinan 250353, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"issue":"9","key":"1","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.2337\/diacare.21.9.1414","volume":"21","year":"1998","journal-title":"Diabetes Care"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.08.059"},{"issue":"1","key":"3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0944-7113(97)80031-1","volume":"4","year":"1997","journal-title":"Phytomedicine"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1080\/10408390902773052"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.40.163"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2005.01.030"},{"key":"7","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1023\/A:1011968313933","volume":"15","year":"1998","journal-title":"Pharmaceutical Research"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1081\/DDC-120001485"},{"issue":"1","key":"9","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1023\/A:1018987928936","volume":"9","year":"1992","journal-title":"Pharmaceutical Research"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20068"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(98)00054-4"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2008.05.001"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2008.06.013"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(02)00130-8"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.09.006"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1021\/cc060089q"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-009-9190-9"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-009-9340-0"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-010-0311-5"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2009.03.001"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(00)00591-3"},{"issue":"8","key":"22","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1080\/03639040500216428","volume":"31","year":"2005","journal-title":"Drug Development and Industrial Pharmacy"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRev.17.273"},{"issue":"2","key":"24","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1042\/bj2080513","volume":"208","year":"1982","journal-title":"Biochemical Journal"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-002-0955-x"}],"container-title":["The Scientific World Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2012\/681534.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2012\/681534.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2012\/681534.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T16:26:07Z","timestamp":1497975967000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/tswj\/2012\/681534\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":25,"alternative-id":["681534","681534"],"URL":"https:\/\/doi.org\/10.1100\/2012\/681534","relation":{},"ISSN":["1537-744X"],"issn-type":[{"value":"1537-744X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}