{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:22:19Z","timestamp":1791904939202,"version":"4.3.4"},"reference-count":25,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Baqiyatallah University of Medical Sciences, Iran"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Diaper dermatitis (DD) is a common inflammatory disorder among children and infants. The objective of the present randomized and double-blind trial was to compare the therapeutic efficacies of<jats:italic>Aloe vera<\/jats:italic>cream and<jats:italic>Calendula officinalis<\/jats:italic>ointment on the frequency and severity of DD in children.<jats:italic>Methods<\/jats:italic>. Sixty-six infants with DD (aged &lt; 3 years) were randomized to receive either<jats:italic>Aloe<\/jats:italic>cream (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>32<\/mml:mn><\/mml:math>) or<jats:italic>Calendula<\/jats:italic>ointment (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>34<\/mml:mn><\/mml:math>). Infants were treated with these drugs 3 times a day for 10 days. The severity of dermatitis was graded at baseline as well as at the end of trial using a 5-point scale. The adverse effects of study medications were assessed during the trial.<jats:italic>Results<\/jats:italic>. Although improvement in the severity of DD was observed in both treatment groups (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>), patients receiving<jats:italic>Calendula<\/jats:italic>ointment had significantly fewer rash sites compared to<jats:italic>Aloe<\/jats:italic>group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>). No adverse effect was reported from either of the medications.<jats:italic>Discussion<\/jats:italic>. The evidence from this study suggests that topical<jats:italic>Aloe<\/jats:italic>and in particular<jats:italic>Calendula<\/jats:italic>could serve as safe and effective treatment for the treatment of diaper dermatitis in infants.<\/jats:p>","DOI":"10.1100\/2012\/810234","type":"journal-article","created":{"date-parts":[[2012,4,19]],"date-time":"2012-04-19T18:03:58Z","timestamp":1334858638000},"page":"1-5","source":"Crossref","is-referenced-by-count":50,"title":["A Randomized Comparative Trial on the Therapeutic Efficacy of Topical<i>Aloe vera<\/i>and<i>Calendula officinalis<\/i>on Diaper Dermatitis in Children"],"prefix":"10.1100","volume":"2012","author":[{"given":"Yunes","family":"Panahi","sequence":"first","affiliation":[{"name":"Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, P.O. Box 19945-581, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad Reza","family":"Sharif","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kashan University of Medical Sciences, P.O. Box 88175-111, Kashan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Sharif","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Kashan University of Medical Sciences, P.O. Box 88175-111, Kashan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Beiraghdar","sequence":"additional","affiliation":[{"name":"Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, P.O. Box 19945-581, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Zahiri","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Branch, Islamic Azad University, P.O. Box 19945-581, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Golnoush","family":"Amirchoopani","sequence":"additional","affiliation":[{"name":"Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, P.O. Box 19945-581, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eisa Tahmasbpour","family":"Marzony","sequence":"additional","affiliation":[{"name":"Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, P.O. Box 19945-581, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences (MUMS), P.O. 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