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Although the molecular lesion is a single-point mutation, the sickle gene is pleiotropic in nature causing multiple phenotypic expressions that constitute the various complications of sickle cell disease in general and sickle cell anemia in particular. The disease itself is chronic in nature but many of its complications are acute such as the recurrent acute painful crises (its hallmark), acute chest syndrome, and priapism. These complications vary considerably among patients, in the same patient with time, among countries and with age and sex. To date, there is no well-established consensus among providers on the management of the complications of sickle cell disease due in part to lack of evidence and in part to differences in the experience of providers. It is the aim of this paper to review available current approaches to manage the major complications of sickle cell disease. We hope that this will establish another preliminary forum among providers that may eventually lead the way to better outcomes.<\/jats:p>","DOI":"10.1100\/2012\/949535","type":"journal-article","created":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T22:00:58Z","timestamp":1343858458000},"page":"1-55","source":"Crossref","is-referenced-by-count":130,"title":["Beyond the Definitions of the Phenotypic Complications of Sickle Cell Disease: An Update on Management"],"prefix":"10.1100","volume":"2012","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1466","authenticated-orcid":true,"given":"Samir K.","family":"Ballas","sequence":"first","affiliation":[{"name":"Cardeza Foundation and Department of Medicine, Thomas Jefferson University, 1015 Walnut Street, Philadelphia, PA 19107, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muge R.","family":"Kesen","sequence":"additional","affiliation":[{"name":"Wilmer Ophthalmological Institute, Johns Hopkins Hospital, 400 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