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We report that CXCL16 is normally expressed on B cells throughout peripheral maturation. Decreased B cell expression of CXCL16 was observed in a subgroup of CVID patients that correlated with defective<jats:italic>in vitro<\/jats:italic>responses to CpG (such as upregulation of CD69, CD86, AICDA, IL-6, and TLR9). 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