{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:08:18Z","timestamp":1784354898420,"version":"3.55.0"},"reference-count":0,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World JOURNAL"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>According to clinical and pathological factors the prognosis of a patient with non-muscle invasive bladder tumors can be assessed. The prognosis is determined by the likelihood of recurrence(30-70%) and\/or progression to muscle invasive bladder cancer(1-15%).Trans urethral resection of bladder tumors remains the initial therapy but adjuvant intravesical instillations are necessary.All patients benefit from a single immediate post operative instillation with a chemotherapeutic agent and for low risk tumors this is the optimal therapy.Patients with intermediate and high risk tumors need more intravesical chemo-or immunotherapy. Chemotherapy reduces recurrences but not progression. Intravesical immunotherapy(BCG) prevents or delays progression. Patients at high risk for progression may need upfront cystectomy.<\/jats:p>","DOI":"10.1100\/tsw.2006.403","type":"journal-article","created":{"date-parts":[[2007,5,26]],"date-time":"2007-05-26T22:03:40Z","timestamp":1180217020000},"page":"2611-2616","source":"Crossref","is-referenced-by-count":1,"title":["Optimal Treatment for Intermediate- and High-Risk, Nonmuscle-Invasive Bladder Cancer"],"prefix":"10.1100","volume":"6","author":[{"given":"A.P.M.","family":"van der Meijden","sequence":"first","affiliation":[{"name":"Department of Urology, Jeroen Bosch Hospital, 5200 ME 's-Hertogenbosch, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","container-title":["The Scientific World JOURNAL"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2006\/879596.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2006\/879596.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T16:15:03Z","timestamp":1471968903000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/tswj\/2006\/879596\/abs\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":0,"alternative-id":["879596"],"URL":"https:\/\/doi.org\/10.1100\/tsw.2006.403","relation":{},"ISSN":["1537-744X"],"issn-type":[{"value":"1537-744X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}