{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:49:20Z","timestamp":1740142160813,"version":"3.37.3"},"reference-count":0,"publisher":"Wiley","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004794","name":"Centre national de la recherche scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005413","name":"Universit\u00e9 Paris Descartes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005413","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UFR Biom\u00e9dicale des Saints-P\u00e8res"},{"DOI":"10.13039\/501100005696","name":"Universit\u00e9 d\u2019Orl\u00e9ans","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005696","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World JOURNAL"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>The mutation extra-toes (Gli3<jats:sup>Xt-J<\/jats:sup>) on chromosome (Chr) 13 of the mouse is known to be involved in the development of the skeleton. The only visible manifestation is the presence of an extra digit on each hind foot. Here we report evidence from several experiments that Gli3<jats:sup>XtJ\/+<\/jats:sup>mice weigh more than littermate Gli3<jats:sup>+\/+<\/jats:sup>mice, suggesting an effect on body weight of<jats:italic>Gli3<\/jats:italic>or of a gene tightly linked to it on Chr 13. Four independent experiments in different environments were conducted on mice with different genetic backgrounds derived from the C3XtEso Gli3<jats:sup>Xt-J\/+<\/jats:sup>E<jats:sup>so\/+<\/jats:sup>linkage testing strain and the JE\/Le strain at adult age. The analyses have shown an association between the Gli3<jats:sup>Xt-J<\/jats:sup>allele and a body weight increase of about 6.5%. This effect is genetically dominant. It would appear that if the gene of interest is not<jats:italic>Gli3<\/jats:italic>itself, it must be very close to this locus. Indeed, the expected size for this fragment is 7.9 \u00b1 5.3 cM. The manifestation of this gene, observed in two animal facilities and on different genetic backgrounds, is consistent with the idea that the effect of the gene(s) is displayed in a stable manner. It accounts for a variation of 6.5% of body weight.<\/jats:p>","DOI":"10.1100\/tsw.2007.40","type":"journal-article","created":{"date-parts":[[2007,5,25]],"date-time":"2007-05-25T07:38:32Z","timestamp":1180078712000},"page":"83-86","source":"Crossref","is-referenced-by-count":3,"title":["Involvement of the<i>Gli3 (Extra-Toes)<\/i>Gene Region in Body Weight in Mice"],"prefix":"10.1100","volume":"7","author":[{"given":"Beno\u00eet","family":"Martin","sequence":"first","affiliation":[{"name":"Laboratoire de Neurobiologie, Universit\u00e9 d'Orl\u00e9ans, B.P. 6759, 45067 Orl\u00e9ans Cedex 2, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eve","family":"Lapouble","sequence":"additional","affiliation":[{"name":"INRA, UMR1079 - Syst\u00e8mes d'Elevage Nutrition Animale et Humaine, 35590 Saint Gilles, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohan","family":"Chaix","sequence":"additional","affiliation":[{"name":"Laboratoire de Neurobiologie, Universit\u00e9 d'Orl\u00e9ans, B.P. 6759, 45067 Orl\u00e9ans Cedex 2, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","container-title":["The Scientific World JOURNAL"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2007\/729503.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2007\/729503.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T10:52:39Z","timestamp":1471949559000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/tswj\/2007\/729503\/abs\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":0,"alternative-id":["729503"],"URL":"https:\/\/doi.org\/10.1100\/tsw.2007.40","relation":{},"ISSN":["1537-744X"],"issn-type":[{"type":"electronic","value":"1537-744X"}],"subject":[],"published":{"date-parts":[[2007]]}}}