{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:17:23Z","timestamp":1771658243416,"version":"3.50.1"},"reference-count":0,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World JOURNAL"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Genetic mutations of the \u03b1 genes are common worldwide. In Asia and particularly Southeast Asia, they can result in clinically significant types of \u03b1-thalassemia, namely hemoglobin (Hb) H disease and Hb Bart's hydrops fetalis. The latter is generally a fatal intrauterine condition, while Hb H disease results in clinical complications that are frequently overlooked. The high prevalence of the carrier state and the burden of these diseases (and other \u03b1-thalassemia variants) call for more attention for improved screening methods and better care.<\/jats:p>","DOI":"10.1100\/tsw.2009.69","type":"journal-article","created":{"date-parts":[[2009,7,20]],"date-time":"2009-07-20T01:03:15Z","timestamp":1248051795000},"page":"615-625","source":"Crossref","is-referenced-by-count":36,"title":["Variable Clinical Phenotypes of \u03b1-Thalassemia Syndromes"],"prefix":"10.1100","volume":"9","author":[{"given":"Sylvia Titi","family":"Singer","sequence":"first","affiliation":[{"name":"Hematology\/Oncology Department, Children's Hospital and Research Center (CHRCO), Oakland, CA, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","container-title":["The Scientific World JOURNAL"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2009\/529605.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2009\/529605.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T10:24:14Z","timestamp":1471947854000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/tswj\/2009\/529605\/abs\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":0,"alternative-id":["529605"],"URL":"https:\/\/doi.org\/10.1100\/tsw.2009.69","relation":{},"ISSN":["1537-744X"],"issn-type":[{"value":"1537-744X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}