{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T10:53:45Z","timestamp":1725447225941},"reference-count":0,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World JOURNAL"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Wegener's granulomatosis (WG) is a systemic, necrotizing, granulomatous vasculitis of unknown etiology. Approximately 75% of cases present as classic WG with both pulmonary and renal involvement, while the remaining 25% of patients present with a limited form with either predominantly upper or lower respiratory tract symptoms. Ninety percent of WG patients have circulating anti\u2013neutrophil cytoplasmic antibodies (ANCA), and approximately 10% have both circulating ANCA antibodies and concomitant anti\u2013glomerular basement membrane (anti-GBM) disease on renal biopsy. Virtually all of these patients also have circulating anti-GBM antibodies. While it has been reported that some patients with ANCA vasculitis have circulating anti-GBM antibodies, and patients with anti-GBM disease may have positive ANCA, review of the literature does not demonstrate other cases of biopsy-proven, simultaneous, ANCA-associated vasculitis and anti-GBM disease. We report a case of simultaneous, biopsy-proven, classic, ANCA-positive WG and anti-GBM disease, but without detectible circulating anti-GBM antibodies. We present findings characteristic of both WG and linear IgG deposition along the GBM suggesting concurrent anti-GBM disease, in the absence of detectable circulating anti-GBM antibodies. Possible theories to explain the absence of these antibodies are discussed.<\/jats:p>","DOI":"10.1100\/tsw.2010.107","type":"journal-article","created":{"date-parts":[[2011,8,15]],"date-time":"2011-08-15T05:32:08Z","timestamp":1313386328000},"page":"1078-1083","source":"Crossref","is-referenced-by-count":2,"title":["A Case of Simultaneous, Biopsy-Proven, Classic, ANCA-Positive Wegener's Granulomatosis and Anti-GBM Disease, but without Detectible Circulating Anti-GBM Antibodies"],"prefix":"10.1100","volume":"10","author":[{"given":"Aleksandra","family":"Gmurczyk","sequence":"first","affiliation":[{"name":"Evanston Northwestern Healthcare, Northwestern University Feinberg School of Medicine, Chicago, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shubhada N.","family":"Ahya","sequence":"additional","affiliation":[{"name":"Evanston Northwestern Healthcare, Northwestern University Feinberg School of Medicine, Chicago, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Goldschmidt","sequence":"additional","affiliation":[{"name":"Evanston Northwestern Healthcare, Northwestern University Feinberg School of Medicine, Chicago, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Kim","sequence":"additional","affiliation":[{"name":"Evanston Northwestern Healthcare, Northwestern University Feinberg School of Medicine, Chicago, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Tammy","family":"Ho","sequence":"additional","affiliation":[{"name":"Evanston Northwestern Healthcare, Northwestern University Feinberg School of Medicine, Chicago, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Nash","sequence":"additional","affiliation":[{"name":"Evanston Northwestern Healthcare, Northwestern University Feinberg School of Medicine, Chicago, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","container-title":["The Scientific World JOURNAL"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2010\/319868.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2010\/319868.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T04:10:06Z","timestamp":1471925406000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/tswj\/2010\/319868\/abs\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":0,"alternative-id":["319868"],"URL":"https:\/\/doi.org\/10.1100\/tsw.2010.107","relation":{},"ISSN":["1537-744X"],"issn-type":[{"value":"1537-744X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}