{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:28:30Z","timestamp":1791106110901,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World JOURNAL"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>\n                    In the last few years, accumulating evidence has shown the existence of an important cross-talk between adenosine A\n                    <jats:sub>2A<\/jats:sub>\n                    receptors (A\n                    <jats:sub>2A<\/jats:sub>\n                    Rs) and brain-derived neurotrophic factor (BDNF). Not only are A\n                    <jats:sub>2A<\/jats:sub>\n                    Rs involved in the mechanism of transactivation of BDNF receptor TrkB, they also modulate the effect of BDNF on synaptic transmission, playing a facilitatory and permissive role. The cAMP-PKA pathway, the main transduction system operated by A\n                    <jats:sub>2A<\/jats:sub>\n                    Rs, is involved in such effects. Furthermore, a basal tonus of A\n                    <jats:sub>2A<\/jats:sub>\n                    Rs is required to allow the regulation of BDNF physiological levels in the brain, as demonstrated by the reduced protein levels measured in A\n                    <jats:sub>2A<\/jats:sub>\n                    Rs KO mice. The crucial role of adenosine A\n                    <jats:sub>2A<\/jats:sub>\n                    Rs in the maintenance of synaptic functions and BDNF levels will be reviewed here and discussed in the light of possible implications for Huntington's disease therapy, in which a joint impairment of BDNF and A\n                    <jats:sub>2A<\/jats:sub>\n                    Rs seems to play a pathogenetic role.\n                  <\/jats:p>","DOI":"10.1100\/tsw.2010.164","type":"journal-article","created":{"date-parts":[[2011,8,15]],"date-time":"2011-08-15T05:32:08Z","timestamp":1313386328000},"page":"1768-1782","source":"Crossref","is-referenced-by-count":34,"title":["Role of Adenosine A\n                    <sub>2A<\/sub>\n                    Receptors in Modulating Synaptic Functions and Brain Levels of BDNF: a Possible Key Mechanism in the Pathophysiology of Huntington's Disease"],"prefix":"10.1100","volume":"10","author":[{"given":"Maria Teresa","family":"Tebano","sequence":"first","affiliation":[{"name":"Department of Therapeutic Research and Medicine Evaluation, Istituto Superiore di Sanit\u00e0, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Martire","sequence":"additional","affiliation":[{"name":"Department of Therapeutic Research and Medicine Evaluation, Istituto Superiore di Sanit\u00e0, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Chiodi","sequence":"additional","affiliation":[{"name":"Department of Therapeutic Research and Medicine Evaluation, Istituto Superiore di Sanit\u00e0, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Ferrante","sequence":"additional","affiliation":[{"name":"Department of Therapeutic Research and Medicine Evaluation, Istituto Superiore di Sanit\u00e0, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Popoli","sequence":"additional","affiliation":[{"name":"Department of Therapeutic Research and Medicine Evaluation, Istituto Superiore di Sanit\u00e0, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","container-title":["The Scientific World JOURNAL"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2010\/507818.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2010\/507818.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T08:44:45Z","timestamp":1471941885000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/tswj\/2010\/507818\/abs\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":0,"alternative-id":["507818"],"URL":"https:\/\/doi.org\/10.1100\/tsw.2010.164","relation":{},"ISSN":["1537-744X"],"issn-type":[{"value":"1537-744X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}