{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:38:03Z","timestamp":1793212683800,"version":"4.5.0"},"reference-count":0,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World JOURNAL"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Rett syndrome (RS) is a neurological disease affecting mainly females, characterized by an arrest of brain development caused by an X-linked mutation. Rett syndrome is the first human disease found to be caused by defects in a protein involved in regulating gene expression through its interaction with methylated DNA. The disease has been traced to a defective gene called MECP2. The case stories presented here and recent findings show that females with RS are able to live into old age. Due to the observed longevity of individuals with RS, and the fact that individuals with RS present the therapist\/physician with specific clinical challenges, it is suggested that proper, long-term, and individually tailored, intensive care should be provided at all ages in the hope to prevent or at least reduce the age-related deterioration that is typical of this population.<\/jats:p>","DOI":"10.1100\/tsw.2010.79","type":"journal-article","created":{"date-parts":[[2011,8,15]],"date-time":"2011-08-15T05:32:08Z","timestamp":1313386328000},"page":"778-787","source":"Crossref","is-referenced-by-count":17,"title":["Aging in Persons with Rett Syndrome: An Updated Review"],"prefix":"10.1100","volume":"10","author":[{"given":"Meir","family":"Lotan","sequence":"first","affiliation":[{"name":"Department of Physical Therapy, Ariel University Center of Samaria, Ariel, Israel"},{"name":"Israeli Rett Syndrome Association, National Evaluation Team, National Rett Syndrome Clinic Chaim Sheba Medical Center, Ramat-Gan, Israel"},{"name":"National Institute of Child Health and Human Development, Office of the Medical Director, Division for Mental Retardation, Ministry of Social Affairs, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joav","family":"Merrick","sequence":"additional","affiliation":[{"name":"National Institute of Child Health and Human Development, Office of the Medical Director, Division for Mental Retardation, Ministry of Social Affairs, Jerusalem, Israel"},{"name":"Kentucky Children's Hospital, University of Kentucky, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isack","family":"Kandel","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Ariel University Center of Samaria, Ariel, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Morad","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Ariel University Center of Samaria, Ariel, Israel"},{"name":"Department of Family Medicine, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","container-title":["The Scientific World JOURNAL"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2010\/238486.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2010\/238486.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T03:13:47Z","timestamp":1471922027000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/tswj\/2010\/238486\/abs\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":0,"alternative-id":["238486"],"URL":"https:\/\/doi.org\/10.1100\/tsw.2010.79","relation":{},"ISSN":["1537-744X"],"issn-type":[{"value":"1537-744X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}