{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T23:27:07Z","timestamp":1770420427660,"version":"3.49.0"},"reference-count":15,"publisher":"Korean Society for Bone and Mineral Research","issue":"2","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["e-jbm.org"],"crossmark-restriction":true},"short-container-title":["J Bone Metab"],"published-print":{"date-parts":[[2022,5,31]]},"abstract":"<jats:p>Atypical parathyroid adenoma (APA) is a rare cause of primary hyperparathyroidism (PHPT) and represents a diagnostic challenge since it is an intermediate form of parathyroid neoplasm of uncertain malignant potential with atypical histological features that require differential diagnosis of parathyroid carcinoma (PC). We present 2 cases of parathyroid crisis as a presentation of APA. The first case was that of a 56-year-old man with parathyroid crisis, constitutional syndrome, and anemia, with evidence of APA after en bloc resection, evolving with hungry bone syndrome after surgery and curation criteria at 6 months after parathyroidectomy (PTX). The second case was a 64-year-old woman with acute chronic kidney disease and parathyroid crisis, with evidence of APA after selective PTX and &gt;50% reduction in parathyroid hormone levels after surgery; however, persistent PHPT at 6 months post-surgery was observed. These cases represented a diagnostic challenge due to their rare clinical presentation (parathyroid crisis), with a heterogeneous spectrum of target organ damage and infrequent symptoms (constitutional syndrome and acute chronic renal disease), in turn caused by a rare pathology (APA). The presentation of these patients may be indicative of PC; however, histopathological diagnosis is a key to the diagnosis of APA. The differential diagnosis of APA vs. PC in clinical practice is indispensable.<\/jats:p>","DOI":"10.11005\/jbm.2022.29.2.133","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T05:12:10Z","timestamp":1654665130000},"page":"133-140","update-policy":"https:\/\/doi.org\/10.11005\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Parathyroid Crisis as Presentation of Atypical Parathyroid Adenoma: Two Diagnostically Challenging Cases"],"prefix":"10.11005","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7954-0795","authenticated-orcid":true,"given":"Galo Andr\u00e9s Salvador","family":"Landeta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1751-6818","authenticated-orcid":true,"given":"Alexis 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literature","author":"Witteveen","year":"2013"}],"container-title":["Journal of Bone 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