{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T19:52:07Z","timestamp":1778356327346,"version":"3.51.4"},"reference-count":42,"publisher":"Korean Society for Bone and Mineral Research","issue":"4","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["e-jbm.org"],"crossmark-restriction":true},"short-container-title":["J Bone Metab"],"published-print":{"date-parts":[[2022,11,30]]},"abstract":"<jats:p>Denosumab is a potent anti-resorptive medication used to treat patients at high risk for osteoporosis; however, its beneficial effects on the skeletal system are quickly reversed after discontinuation. In contrast, bisphosphonates (BPs) are anti-resorptive agents with residual effects on the bone matrix; thus, these are capable of preserving bone mass for a long time. Therefore, subsequent anti-resorptive treatment with BPs is mandatory to prevent rebound fractures. Furthermore, BP administration before denosumab treatment appears to be a reasonable strategy for reducing hyperactivation of bone remodeling. In this review, we summarize the effects of BP administration before denosumab treatment in preventing rebound fractures after denosumab discontinuation.<\/jats:p>","DOI":"10.11005\/jbm.2022.29.4.217","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T23:58:12Z","timestamp":1670543892000},"page":"217-223","update-policy":"https:\/\/doi.org\/10.11005\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Role of Bisphosphonates Prior to Denosumab Treatment on Rebound Fractures: A Mini Review"],"prefix":"10.11005","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7158-1530","authenticated-orcid":true,"given":"Arthur Costa","family":"Inojosa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3568-7979","authenticated-orcid":true,"given":"La\u00eds","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1035-4921","authenticated-orcid":true,"given":"Leonardo","family":"Bandeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0290-0742","authenticated-orcid":true,"given":"Francisco","family":"Bandeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4758","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-014-2794-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-013-0136-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1502"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-8587(17)30138-9"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10010152"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1177\/1759720x11424220"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12873"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-016-1030-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-019-0676-0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-018-04820-8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2020.10.014"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-015-3459-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-015-3380-y"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-018-0389-1"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-3170"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-020-02333-1"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2020.100267"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13867"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.04.007"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3110"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2015.01.032"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.1.20"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1080\/09243860500096289"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R109.041087"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3337"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4335"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-019-00502-4"},{"key":"ref28","first-page":"S408","volume-title":"Rebound-associated bone loss after non-renewal of long-term denosumabtreatment offsets 10-year gains at the total hip within 12 months","author":"Popp","year":"2016"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-016-3535-5"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2017.03.006"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-020-01126-w"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3962"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-020-00785-1"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2020.100290"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.06.018"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-017-4080-6"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-018-0409-1"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-015-3174-2"},{"key":"ref39","first-page":"115","volume-title":"Can we avoid the loss of bone mineral density one year after denosumab discontinuation? The ReoLaus Bone Project","author":"Aubry-Rozier","year":"2019"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.115150"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1530\/endoabs.56.p188"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2019.02.007"}],"container-title":["Journal of Bone Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-jbm.org\/upload\/pdf\/jbm-2022-29-4-217.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-jbm.org\/journal\/view.php?doi=10.11005\/jbm.2022.29.4.217","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-jbm.org\/upload\/pdf\/jbm-2022-29-4-217.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T02:26:40Z","timestamp":1670984800000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-jbm.org\/journal\/view.php?doi=10.11005\/jbm.2022.29.4.217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,30]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,11]]}},"URL":"https:\/\/doi.org\/10.11005\/jbm.2022.29.4.217","relation":{},"ISSN":["2287-6375","2287-7029"],"issn-type":[{"value":"2287-6375","type":"print"},{"value":"2287-7029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,30]]},"assertion":[{"value":"2022-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-30","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-30","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}