{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:53:40Z","timestamp":1781758420006,"version":"3.54.5"},"reference-count":11,"publisher":"Korean Society for Bone and Mineral Research","issue":"2","license":[{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Government of India Ministry of Science and Technology, Department of Biotechnology","award":["BT\/INF\/22\/SP43075\/2021"],"award-info":[{"award-number":["BT\/INF\/22\/SP43075\/2021"]}]}],"content-domain":{"domain":["e-jbm.org"],"crossmark-restriction":true},"short-container-title":["JBM"],"published-print":{"date-parts":[[2026,5,31]]},"abstract":"<jats:p>Background: Osteoporosis is highly prevalent among Indian women and is further exacerbated by cancer-directed therapies such as chemotherapy, hormonal therapy, and radiotherapy. Patients with breast cancer are particularly susceptible to bone loss. While dual energy X-ray absorptiometry (DXA) remains the gold standard, it does not assess bone microarchitecture. High-resolution peripheral quantitative computed tomography (HR-pQCT) may provide additional insights.Methods: This cross-sectional pilot study was conducted between May and December 2024 at a tertiary care center and included 54 women with breast cancer without bone metastases. Demographic, clinical, and treatment data were recorded. All patients underwent DXA and HR-pQCT scans to assess bone density and microarchitecture. Statistical analysis included subgroup comparisons and concordance testing.Results: Mean age was 55.8\u00b111 years, and 65% were postmenopausal. Estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 positivity rates were 76%, 57%, and 28%, respectively. Osteoporosis was found in 38.2% and osteopenia in 61.8% by DXA. HR-pQCT revealed lower volumetric bone density (0.59\u00b10.07 g\/cm\u00b3) compared to DXA (0.84\u00b10.16 g\/cm\u00b3, P&lt;0.01). Microarchitectural deficits were significant in postmenopausal women, chemotherapy recipients, and those on letrozole. Lin\u2019s concordance correlation indicated poor agreement between HR-pQCT and DXA (&lt;0.9).Conclusions: HR-pQCT was superior to DXA in detecting microarchitectural deterioration in women with breast cancer. This pilot study emphasizes the need for larger prospective studies in Indian cohorts.<\/jats:p>","DOI":"10.11005\/jbm.25.955","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:27:11Z","timestamp":1780964831000},"page":"188-196","update-policy":"https:\/\/doi.org\/10.11005\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bone Health in Breast Cancer Patients: Comparative Evaluation Using Dual Energy X-Ray Absorptiometry Scan and High-Resolution Peripheral Quantitative Computed Tomography"],"prefix":"10.11005","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1113-0559","authenticated-orcid":true,"given":"Sunaina","family":"Kumari","sequence":"first","affiliation":[{"name":"Department of Endocrine and Breast Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2621-394X","authenticated-orcid":true,"given":"Sabaretnam","family":"Mayilvaganan","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Breast Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1905-9147","authenticated-orcid":true,"given":"Sushil","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6840-5406","authenticated-orcid":true,"given":"Manisha","family":"Kakaji","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4605-3816","authenticated-orcid":true,"given":"Gyan","family":"Chand","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Breast Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5751-756X","authenticated-orcid":true,"given":"Anjali","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Breast Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9525-5466","authenticated-orcid":true,"given":"Gaurav","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Breast Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4758","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.137485","type":"journal-article"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650090802","type":"journal-article"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2001.19.14.3306","type":"journal-article"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2013.36","type":"journal-article"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu103","type":"journal-article"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr017","type":"journal-article"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2008.18.4184","type":"journal-article"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1258","type":"journal-article"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-013-0142-7","type":"journal-article"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2007.12.010","type":"journal-article"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2019.12.001","type":"journal-article"}],"container-title":["Journal 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