{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:02:42Z","timestamp":1789524162945,"version":"build-2803163510"},"reference-count":55,"publisher":"Korean Society for Bone and Mineral Research","issue":"3","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010874","name":"American Society for Bone and Mineral Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010874","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Instituto Nacional de la Yerba Mate"},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Rosario National University"}],"content-domain":{"domain":["e-jbm.org"],"crossmark-restriction":true},"short-container-title":["JBM"],"published-print":{"date-parts":[[2026,8,31]]},"abstract":"<jats:p>Background: Oxidative stress contributes to bone loss, and dietary antioxidants may support skeletal health. This study evaluated the effects of yerba mate (YM) infusion with enhanced antioxidant capacity (AOC; YM+) on skeletal outcomes. Methods: Female Sprague-Dawley rats (6 weeks old) were randomized into three groups: control (water), YM, and YM+. After 90 days, tibial bone mineral density (BMD), biomechanical strength, histomorphometry, and plasma oxidative stress\/antioxidant markers were assessed. Data were analyzed by analysis of variance (&lt;i&gt;p&lt;\/i&gt;&lt;0.05). Results: Both YM and YM+ groups showed significantly higher tibial BMD vs. control (YM, +10.1%; YM+, +9.1%; &lt;i&gt;p&lt;\/i&gt;&lt;0.05). Plasma thiobarbituric acid reactive substances decreased (46% in YM, 55% in YM+), indicating reduced lipid peroxidation. Although YM+ had higher ferric reducing antioxidant power values and total polyphenol content (TPC), skeletal outcomes did not differ between YM and YM+. TPC and alkaline phosphatase (ALP) increased significantly in a dose-dependent manner: TPC (\u03bcg\/mL gallic acid equivalent): control 456\u00b143.2; YM, 577\u00b145.0; YM+, 634\u00b144.4; ALP (IU\/L): 0.201\u00b10.010; 0.265\u00b10.049; 0.321\u00b10.051. Histomorphometry showed no differences in trabecular volume, thickness, number, or separation. Conclusions: regular YM consumption improved BMD and vertebral mechanical strength. However, increasing AOC did not enhance additional skeletal benefits, indicating that increased AOC did not translate into additional skeletal benefits under the experimental conditions tested. These findings support YM as a potential dietary strategy to promote bone health.<\/jats:p>","DOI":"10.11005\/jbm.25.981","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T04:25:12Z","timestamp":1788755112000},"page":"234-245","update-policy":"https:\/\/doi.org\/10.11005\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Yerba Mate and Bone Health: Can Antioxidant Capacity Influence Skeletal Outcomes?"],"prefix":"10.11005","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1114-319X","authenticated-orcid":true,"given":"Mercedes","family":"Lombarte","sequence":"first","affiliation":[{"name":"Bone Biology Laboratory, School of Medicine, Rosario National University, Rosario, Santa Fe, Argentina"},{"name":"National Council of Scientific and Technical Research (CONICET), Rosario, Santa Fe, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8134-0657","authenticated-orcid":true,"given":"Laureana","family":"Villarreal","sequence":"additional","affiliation":[{"name":"Bone Biology Laboratory, School of Medicine, Rosario National University, Rosario, Santa Fe, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3793-3250","authenticated-orcid":true,"given":"Agustina","family":"Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"Bone Biology Laboratory, School of Medicine, Rosario National University, Rosario, Santa Fe, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0637-3178","authenticated-orcid":true,"given":"Patricia M.","family":"Lupi\u00f3n","sequence":"additional","affiliation":[{"name":"Bone Biology Laboratory, School of Medicine, Rosario National University, Rosario, Santa Fe, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1233-1750","authenticated-orcid":true,"given":"Ver\u00f3nica E.","family":"Di Loreto","sequence":"additional","affiliation":[{"name":"Bone Biology Laboratory, School of Medicine, Rosario National University, Rosario, Santa Fe, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6281-2096","authenticated-orcid":true,"given":"Lucas R.","family":"Brun","sequence":"additional","affiliation":[{"name":"Bone Biology Laboratory, School of Medicine, Rosario National University, Rosario, Santa Fe, Argentina"},{"name":"National Council of Scientific and Technical Research (CONICET), Rosario, Santa Fe, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4758","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0172-4","type":"journal-article"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.06.032","type":"journal-article"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/s0367-326x(01)00331-8","type":"journal-article"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2007.00535.x","type":"journal-article"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-015-0588-9","type":"journal-article"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.15694","type":"journal-article"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/s0031-9422(00)00324-1","type":"journal-article"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/jaoac\/83.5.1167","type":"journal-article"},{"key":"ref9","first-page":"21","type":"journal-article","volume-title":"Fraction of minerals extracted from Paraguayan yerba mate (Ilex paraguariensis, S.H.) by cold tea (maceration) and hot tea (infusion) as consumed in Paraguay","author":"Vera Garcia","year":"2005"},{"key":"ref10","first-page":"383","type":"book","volume-title":"Chapter 10 - Insights into yerba mate components: Chemistry and food applications","author":"Galante","year":"2023"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.11005\/jbm.24.827","type":"journal-article"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.08.029","type":"journal-article"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-015-0043-0","type":"journal-article"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2017.07.006","type":"journal-article"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115709","type":"journal-article"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510280042030","type":"journal-article"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2002.10719252","type":"journal-article"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2012.31612","type":"journal-article"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21326","type":"journal-article"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.11005\/jbm.2024.31.2.101","type":"journal-article"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1590\/1678-4324-2021200802","type":"journal-article"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/1749-799x-1-7","type":"journal-article"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3390\/antiox3010144","type":"journal-article"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2011.02.033","type":"journal-article"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.058255","type":"journal-article"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12033","type":"journal-article"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1021\/jf00062a013","type":"journal-article"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1021\/jf000220w","type":"journal-article"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1996.0292","type":"journal-article"},{"key":"ref30","volume-title":"","author":"Olfert","year":"1993","type":"book"},{"key":"ref31","volume-title":"","year":"2011","type":"book"},{"key":"ref32","volume-title":"","author":"Rigalli","year":"2009","type":"book"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/128.6.1003","type":"journal-article"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90738-3","type":"journal-article"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100768","type":"journal-article"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-024-04736-3","type":"journal-article"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1805","type":"journal-article"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(93)90081-k","type":"journal-article"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.2.284","type":"journal-article"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2005.10.002","type":"journal-article"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.3390\/foods9070953","type":"journal-article"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200900583","type":"journal-article"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(87)90155-3","type":"journal-article"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.20960\/nh.1219","type":"journal-article"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2013.09.007","type":"journal-article"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1021\/jf803096g","type":"journal-article"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2011.10.017","type":"journal-article"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.3390\/foods12051072","type":"journal-article"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00494","type":"journal-article"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-022-06399-7","type":"journal-article"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2022.11.008","type":"journal-article"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqac189","type":"journal-article"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.mic-path.2024.106564","type":"journal-article"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2024.109601","type":"journal-article"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt071","type":"journal-article"}],"container-title":["Journal of Bone Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.e-jbm.org\/upload\/pdf\/jbm-25-981.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.e-jbm.org\/journal\/view.php?doi=10.11005\/jbm.25.981","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.e-jbm.org\/upload\/pdf\/jbm-25-981.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:30:37Z","timestamp":1789522237000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.e-jbm.org\/journal\/view.php?doi=10.11005\/jbm.25.981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,8]]}},"URL":"https:\/\/doi.org\/10.11005\/jbm.25.981","relation":{},"ISSN":["2287-6375","2287-7029"],"issn-type":[{"value":"2287-6375","type":"print"},{"value":"2287-7029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]},"assertion":[{"value":"2025-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}