{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T06:34:26Z","timestamp":1773729266912,"version":"3.50.1"},"reference-count":27,"publisher":"Korean Society for Bone and Mineral Research","issue":"1","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1A2C3005727"],"award-info":[{"award-number":["2021R1A2C3005727"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00454010"],"award-info":[{"award-number":["RS-2024-00454010"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korean Fund for Regenerative Medicine","award":["22A0104L1"],"award-info":[{"award-number":["22A0104L1"]}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-jbm.org"],"crossmark-restriction":true},"short-container-title":["JBM"],"published-print":{"date-parts":[[2026,2,28]]},"abstract":"<jats:p>Background: Although various surface modifications enhance titanium (Ti) implant osseointegration, achieving rapid bone formation comparable to native healing remains challenging. Current strategies primarily focus on micro-scale topography, often overlooking the critical role of macroscopic three-dimensional (3D) architecture in osteoconduction.Methods: We hypothesized that mimicking native bone\u2019s porous architecture is key to accelerating osseointegration. First, we verified the impact of structural continuity by comparing standard Ti implants with decellularized bone grafts in a mouse calvaria defect model. Subsequently, we developed a biomimetic polycaprolactone (PCL)-based 3D architectural cover (Cover-type) and evaluated its osseointegration efficacy in a rat femur model against conventional Ti implants.Results: The mouse study confirmed that decellularized bone integrated significantly faster than Ti, highlighting the necessity of 3D continuity. In the rat model, micro-computed tomography analysis indicated a clear trend of increased bone formation in the Cover-type group, though statistical significance was limited by sample size. However, histological analysis confirmed a statistically significant enhancement in bone-to-implant contact compared to controls (P&lt;0.05). The PCL structure served as a scaffold for cell migration, effectively bridging the implant-bone gap.Conclusions: These findings suggest that providing a bone-like 3D environment via a PCL cover may enhance histological osseointegration, rather than relying solely on surface chemistry.<\/jats:p>","DOI":"10.11005\/jbm.26.1003","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T07:23:53Z","timestamp":1773041033000},"page":"30-39","update-policy":"https:\/\/doi.org\/10.11005\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomimetic Architectural Cover Accelerates Osseointegration of Titanium Implants"],"prefix":"10.11005","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9641-7531","authenticated-orcid":true,"given":"Su-Jin","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5419-0530","authenticated-orcid":true,"given":"Eun Chae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7520-3974","authenticated-orcid":true,"given":"Weon-Young","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4055-9365","authenticated-orcid":true,"given":"Seung-Jae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8708-8943","authenticated-orcid":true,"given":"Je-Hwang","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4758","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2019.03.008"},{"key":"ref2","first-page":"169","volume-title":"Implant loading protocols for the partially edentulous esthetic zone","author":"Gr\u00fctter","year":"2009"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-8-32"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1556\/imas.5.2013.4.3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/791725"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1320307"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2003.00972.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.01082.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/j.0022-0337.2003.67.8.tb03681.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5413.77129"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/bot.0000000000001420"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEB.2012.0012"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1177\/2041731416680306"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2010.04.002"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2018.00172"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.07.021"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.973297"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/s1350-4533(98)00007-1"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.01.039"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820040309"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038\/srep34072"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a021589"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00502.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.4103\/jispcd.JISPCD_96_21"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3390\/ma18010119"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s13191-013-0252-z"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/ad2537"}],"container-title":["Journal of Bone Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-jbm.org\/upload\/pdf\/jbm-26-1003.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-jbm.org\/journal\/view.php?doi=10.11005\/jbm.26.1003","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-jbm.org\/upload\/pdf\/jbm-26-1003.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T04:55:18Z","timestamp":1773723318000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-jbm.org\/journal\/view.php?doi=10.11005\/jbm.26.1003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,28]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"URL":"https:\/\/doi.org\/10.11005\/jbm.26.1003","relation":{},"ISSN":["2287-6375","2287-7029"],"issn-type":[{"value":"2287-6375","type":"print"},{"value":"2287-7029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,28]]},"assertion":[{"value":"2025-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-28","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-28","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}