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Remarkably, we found that TOP3B is required for efficient replication of all positive-sense-single stranded RNA viruses tested, including SARS-CoV-2. While there are no drugs that specifically inhibit this topoisomerase, we posit that TOP3B is an attractive anti-viral target.<\/jats:p>","DOI":"10.1101\/2020.03.24.005900","type":"posted-content","created":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T15:45:11Z","timestamp":1585323911000},"source":"Crossref","is-referenced-by-count":3,"title":["Topoisomerase III-\u00df is required for efficient replication of positive-sense RNA viruses"],"prefix":"10.64898","author":[{"given":"K. Reddisiva","family":"Prasanth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minato","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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