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We used TRABI for continuous seromonitoring of hospital patients and healthy blood donors (n=72\u2019222) in the canton of Zurich from December 2019 to December 2020 (pre-vaccine period). Seroprevalence peaked in May 2020 and rose again in November 2020 in both cohorts. Validations of results included antibody diffusional sizing and Western Blotting. Using an extended Susceptible-Exposed-Infectious-Removed model, we found that antibodies waned with a half-life of 75 days, whereas the cumulative incidence rose from 2.3% in June 2020 to 12.2% in mid-December 2020 in the population of the canton of Zurich. A follow-up health survey indicated that about 10% of patients infected with wildtype SARS-CoV-2 sustained some symptoms at least twelve months post COVID-19 and up to the timepoint of survey participation. Crucially, we found no evidence for a difference in long-term complications between those whose infection was symptomatic and those with asymptomatic acute infection. The cohort of asymptomatic SARS-CoV-2- infected subjects represents a resource for the study of chronic and possibly unexpected sequelae.<\/jats:p>","DOI":"10.1101\/2020.05.31.20118554","type":"posted-content","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T13:36:07Z","timestamp":1591104967000},"source":"Crossref","is-referenced-by-count":23,"title":["Continuous population-level monitoring of SARS-CoV-2 seroprevalence in a large metropolitan region"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6073-8811","authenticated-orcid":false,"given":"Marc","family":"Emmenegger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena De","family":"Cecco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Lamparter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rapha\u00ebl P. 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