{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T06:45:34Z","timestamp":1768545934521,"version":"3.49.0"},"posted":{"date-parts":[[2020,6,4]]},"group-title":"Infectious Diseases (except HIV\/AIDS)","reference-count":21,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2022,5,18]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>The current SARS-CoV-2 pandemic has highlighted a need for easy and safe blood sampling in combination with accurate serological methodology. Venipuncture is usually performed by trained staff at health care centers. Long travel distances may introduce a bias of testing towards relatively large communities with close access to health care centers. Rural regions may thus be overlooked. Here, we demonstrate a sensitive method to measure antibodies to the S-protein of SARS-CoV-2. We adapted and optimized this assay for clinical use together with capillary blood sampling to meet the geographical challenges of serosurveillance. Finally, we tested remote at-home capillary blood sampling together with centralized assessment of S-specific IgG in a rural region of northern Scandinavia that encompasses 55,185 sq kilometers. We conclude that serological assessment from capillary blood sampling gives comparable results as analysis of venous blood. Importantly, at-home sampling enabled citizens living in remote rural areas access to centralized and sensitive laboratory antibody tests.<\/jats:p>","DOI":"10.1101\/2020.06.02.20120477","type":"posted-content","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T11:25:40Z","timestamp":1591269940000},"source":"Crossref","is-referenced-by-count":8,"title":["Serological assessment of SARS-CoV-2 exposure in northern Sweden by the use of at-home sampling to meet geographical challenges in rural regions"],"prefix":"10.64898","author":[{"given":"Julia 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