{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T15:47:21Z","timestamp":1768492041893,"version":"3.49.0"},"posted":{"date-parts":[[2020,7,6]]},"group-title":"Genomics","reference-count":53,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2020,7,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>To identify features in the genome of the SARS-CoV-2 pathogen responsible for the COVID-19 pandemic that may contribute to its viral replication, host pathogenicity, and vulnerabilities, we investigated how and to what extent the SARS-CoV-2 genome sequence differs from other well-characterized human and animal coronavirus genomes. Our analyses suggest the presence of unique sequence signatures in the 3\u2019-untranslated region (UTR) of betacoronavirus lineage B, which phylogenetically encompasses SARS-CoV-2, SARS-CoV, as well as multiple groups of bat and animal coronaviruses. In addition, we identified genome-wide patterns of variation across different SARS-CoV-2 strains that likely reflect the effects of selection. Finally, we provide evidence for a possible host microRNA-mediated interaction between the 3\u2019-UTR and human microRNA hsa-miR-1307-3p based on predicted, yet extensive, complementary base-pairings and similar interactions involving the Influenza A H1N1 virus. This interaction also suggests a possible survival mechanism, whereby a mutation in the SARS-CoV-2 3\u2019-UTR leads to a weakened host immune response. The potential roles of host microRNAs in SARS-CoV-2 replication and infection, and the exploitation of conserved features in the 3\u2019-UTR as therapeutic targets warrant further investigation.<\/jats:p>","DOI":"10.1101\/2020.07.06.190207","type":"posted-content","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T01:17:34Z","timestamp":1594084654000},"source":"Crossref","is-referenced-by-count":6,"title":["Conserved Genomic Terminals of SARS-CoV-2 as Co-evolving Functional Elements and Potential Therapeutic Targets"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2373-9580","authenticated-orcid":false,"given":"Agnes. 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