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IgA responses in plasma generally correlate with IgG responses and clones of IgM, IgG and IgA producing B cells that are derived from common progenitors are evident. Plasma IgA monomers are 2-fold less potent than IgG equivalents. However, IgA dimers, the primary form in the nasopharynx, are on average 15 times more potent than IgA monomers. Thus, secretory IgA responses may be particularly valuable for protection against SARS-CoV-2 and for vaccine efficacy.<\/jats:p>","DOI":"10.1101\/2020.09.09.288555","type":"posted-content","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T05:07:16Z","timestamp":1599714436000},"source":"Crossref","is-referenced-by-count":25,"title":["Enhanced SARS-CoV-2 Neutralization by Secretory IgA in vitro"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2095-2151","authenticated-orcid":false,"given":"Zijun","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2492-3961","authenticated-orcid":false,"given":"Julio C. 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