{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T16:16:13Z","timestamp":1768493773880,"version":"3.49.0"},"posted":{"date-parts":[[2020,11,10]]},"group-title":"Immunology","reference-count":27,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2020,11,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Studies on human monocytes historically focused on characterization of bulk responses, whereas functional heterogeneity is largely unknown. Here, we identified an inducible population of CD127-expressing human monocytes under inflammatory conditions and named the subset M127. M127 is nearly absent in healthy individuals yet abundantly present in patients with infectious and inflammatory conditions such as COVID-19 and rheumatoid arthritis. Multiple genomic and functional approaches revealed unique gene signatures of M127 and unified anti-inflammatory properties imposed by the CD127-STAT5 axis. M127 expansion correlated with mild COVID-19 disease outcomes. Thereby, we phenotypically and molecularly characterized a human monocyte subset marked by CD127 that retained anti-inflammatory properties within the pro-inflammatory environments, uncovering remarkable functional diversity among monocytes and signifying M127 as a potential therapeutic target for human inflammatory disorders.<\/jats:p>","DOI":"10.1101\/2020.11.10.376277","type":"posted-content","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T02:00:14Z","timestamp":1605060014000},"source":"Crossref","is-referenced-by-count":3,"title":["CD127 imprints functional heterogeneity to diversify monocyte responses in human inflammatory diseases"],"prefix":"10.64898","author":[{"given":"Bin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzhe","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunliang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiuliang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xindong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haofei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Fang","family":"Ping","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiangfeng Cliff","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu-Wu","family":"Bian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2024080423262340000_2020.11.10.376277v1.1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0331-4"},{"key":"2024080423262340000_2020.11.10.376277v1.2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41584-019-0217-7","article-title":"Insights into rheumatic diseases from next-generation sequencing","volume":"15","year":"2019","journal-title":"Nat Rev Rheumatol"},{"key":"2024080423262340000_2020.11.10.376277v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.71"},{"key":"2024080423262340000_2020.11.10.376277v1.4","doi-asserted-by":"publisher","DOI":"10.1038\/nri3070"},{"key":"2024080423262340000_2020.11.10.376277v1.5","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.36"},{"key":"2024080423262340000_2020.11.10.376277v1.6","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-417028-5.00003-X"},{"key":"2024080423262340000_2020.11.10.376277v1.7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132557"},{"key":"2024080423262340000_2020.11.10.376277v1.8","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.immuni.2018.10.005","article-title":"Developmental and Functional Heterogeneity of Monocytes","volume":"49","year":"2018","journal-title":"Immunity"},{"key":"2024080423262340000_2020.11.10.376277v1.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.02.029"},{"key":"2024080423262340000_2020.11.10.376277v1.10","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.immuni.2020.05.002","article-title":"Immunology of COVID-19: Current State of the Science","volume":"52","year":"2020","journal-title":"Immunity"},{"key":"2024080423262340000_2020.11.10.376277v1.11","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/s41590-019-0479-x","article-title":"Flip the coin: IL-7 and IL-7R in health and disease","volume":"20","year":"2019","journal-title":"Nat Immunol"},{"key":"2024080423262340000_2020.11.10.376277v1.12","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.169"},{"key":"2024080423262340000_2020.11.10.376277v1.13","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0378-1"},{"key":"2024080423262340000_2020.11.10.376277v1.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.05.031"},{"key":"2024080423262340000_2020.11.10.376277v1.15","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016261"},{"key":"2024080423262340000_2020.11.10.376277v1.16","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.1038\/s41467-019-12630-7","article-title":"SCALE method for single-cell ATAC-seq analysis via latent feature extraction","volume":"10","year":"2019","journal-title":"Nat Commun"},{"key":"2024080423262340000_2020.11.10.376277v1.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.09.009"},{"key":"2024080423262340000_2020.11.10.376277v1.18","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/s41591-020-0901-9","article-title":"Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19","volume":"26","year":"2020","journal-title":"Nat Med"},{"key":"2024080423262340000_2020.11.10.376277v1.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.09.034"},{"key":"2024080423262340000_2020.11.10.376277v1.20","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"2024080423262340000_2020.11.10.376277v1.21","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2009-10-3-r25"},{"key":"2024080423262340000_2020.11.10.376277v1.22","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2013-14-4-r36"},{"key":"2024080423262340000_2020.11.10.376277v1.23","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt656"},{"key":"2024080423262340000_2020.11.10.376277v1.24","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"2024080423262340000_2020.11.10.376277v1.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.05.004"},{"key":"2024080423262340000_2020.11.10.376277v1.26","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2012.016"},{"key":"2024080423262340000_2020.11.10.376277v1.27","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2020.11.10.376277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:02:02Z","timestamp":1768438922000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2020.11.10.376277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,10]]},"references-count":27,"URL":"https:\/\/doi.org\/10.1101\/2020.11.10.376277","relation":{},"subject":[],"published":{"date-parts":[[2020,11,10]]},"subtype":"preprint"}}